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Zh Nevrol Psikhiatr Im S S Korsakova ; 113(10 Pt 2): 47-51, 2013.
Article in Russian | MEDLINE | ID: mdl-24300815

ABSTRACT

The expression of CD100 semaphorin by the intact peripheral blood T lymphocytes in multiple sclerosis (MS) has been studied. The level of middle florescence intensity (MFI) and the number of B-lymphocytes bearing CD72 were evaluated. There were significant differences in the level of CD100 in patients compared to healthy volunteers. These data suggest the use of semaphorin as a possible therapeutic target in pathological inflammation in MS.


Subject(s)
Antigens, CD/biosynthesis , Immunity, Cellular , Multiple Sclerosis, Relapsing-Remitting/immunology , Semaphorins/biosynthesis , T-Lymphocytes/immunology , Adult , Antigens, CD/immunology , Antigens, Differentiation, B-Lymphocyte/immunology , Female , Humans , Lymphocyte Activation , Male , Middle Aged , Multiple Sclerosis, Relapsing-Remitting/blood , Semaphorins/immunology
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