ABSTRACT
The aim of the study was to evaluate concentrations of atrial natriuretic peptide (ANP) and endothelin in blood serum of the patients with nonatopic bronchial asthma in the exacerbation phase and during non-symptomatic period. The study included 20 patients with nonatopic bronchial asthma (10 women and 10 men, mean age 34.2) treated in the Allergological Outpatient Clinic in Zabrze (Poland). A control group consisted of 5 healthy volunteers without atopy. The study consisted of evaluation of the ANP and endothelin in blood serum by radioimmunoassay and by functional respiratory tests. It was shown that ANP concentrations during bronchial asthma exacerbation were two times lower than in the same group examined in the remission phase (7.8-13.7 pmol/ml, p < 0.05). At the time of bronchospastic symptoms occurrence, the concentrations of endothelin were statistically significant and higher than in the non-symptomatic group (11.6-6.9 pmol/ml, p < 0.05). In the examined group the reverse proportion relation between concentrations of the studied peptides in blood serum was observed r = -0.56, p < 0.05 according to Spearman test.
Subject(s)
Asthma/blood , Atrial Natriuretic Factor/blood , Endothelin-1/blood , Acute Disease , Adolescent , Adult , Analysis of Variance , Female , Humans , Male , Middle AgedABSTRACT
The therapeutic approach of immunoprophylaxis by means of bacterial lysate, rybosomal extracts etc. in chronic respiratory diseases and immunomodulatory mode of action of bacterial vaccines are presented.
Subject(s)
Bacterial Vaccines/therapeutic use , Immunotherapy/methods , Respiratory Tract Diseases/therapy , Bacterial Infections/complications , Chronic Disease , Humans , Respiratory Tract Diseases/microbiologySubject(s)
Carrier Proteins/metabolism , Membrane Glycoproteins , Membrane Transport Proteins , Nerve Tissue Proteins , Symporters , Animals , Biological Transport , Carrier Proteins/genetics , Cell Line , Dopamine/metabolism , Dopamine Plasma Membrane Transport Proteins , Electrochemistry/instrumentation , Electrochemistry/methods , Humans , Indicators and Reagents , Kinetics , Norepinephrine/metabolism , Norepinephrine Plasma Membrane Transport Proteins , Recombinant Proteins/metabolism , Transfection/methodsABSTRACT
In 34 patients, 25 males and 9 females, aged 12-24 years (mean 15.9) 3-5 years after the completion of acute lymphoblastic leukemia treatment the non-invasive evaluation of cardiovascular system was done with the use of electrocardiography, echocardiography and treadmill stress test. The cumulative anthracycline doses varied from 149 to 417 mg/m2, mean 250 mg/m2. The control group consisted of 28 healthy volunteers, 15 males and 13 females aged 9-25 years (mean 17.0). The history, physical examination and non-invasive tests' results did not revealed the cardiomyopathy signs, left ventricle contractility in the study and control groups did not differ significantly. Treadmill stress test showed lower maximal heart rate achieved and deeper ST segment depression in the study group. We conclude that the patients after leukemia treatment need further careful investigations.
Subject(s)
Cardiovascular Diseases/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Adolescent , Adult , Cardiovascular Diseases/complications , Child , Echocardiography , Electrocardiography , Exercise Test , Female , Heart Rate/physiology , Humans , Male , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Retrospective StudiesSubject(s)
Carrier Proteins/physiology , Dopamine/metabolism , Dopamine/pharmacology , Symporters , Amphetamine/pharmacology , Carrier Proteins/drug effects , Cell Line , Dopamine/analogs & derivatives , Dopamine/pharmacokinetics , Electrophysiology/methods , Humans , Kinetics , Methylphenidate/pharmacology , Norepinephrine/metabolism , Norepinephrine Plasma Membrane Transport Proteins , Phenethylamines/pharmacology , Psychotropic Drugs/pharmacologyABSTRACT
The medieval preventive medical scheme which persisted up to the period of Enlightenment, called the "Six Things Non-natural and Necessary", comprised six items whose influence on the health of the individual is not inborn (not determined by innateness), but no one can avoid facing them in his life (hence, they are "necessary"); however, they may be tackled in ways either promoting or impairing health (viz.: air, food, exercise, sleep, emotions, cleansing and sexuality). The taxative list of "Six Things" is normalized in book Six of Hippocratic "Epidemics"; later, the topos was furthered by Galen, John of Alexandria (and other Alexandrinian authors) and Hunain ibn Ishaq. At least nine authors in Bohemia, Moravia and Slovakia divulged the "Six Non-natural Necessary Things" from the 15th to the end of the 18th century. Due to the re-evaluation of "naturalness" on the break from Enlightenment to Romantism, the concept of "non-natural" conditions of health was abandoned; during the period of analytical medicine relevant questions were side-tracked; only the "re-synthetical" medicine (in the second half of the 20th c.) restored the original intuitive scheme of "Six Non-natural and Necessary" conditions of health in the new form of the "risk factors of health relevant behaviour".
Subject(s)
Health , Philosophy, Medical , History, 16th Century , History, 17th Century , History, 18th Century , History, 19th Century , History, Ancient , History, Medieval , Humans , Medicine, ArabicSubject(s)
Emblems and Insignia/history , Mythology , Snakes , Animals , History of Pharmacy , History, Ancient , Medicine in the Arts , Religion and MedicineABSTRACT
In order to analyze the relationship between VO2 max and height, body mass and lean body mass a multi-longitudinal survey was conducted on three different age groups of randomly selected children from a small Czech community. Beginning at the initial ages of 8, 12 and 16 years subjects were subsequently retested three times at two year intervals. At overlapping ages there were no differences in the various age groups between height and VO2 max. By utilizing mean values for the various parameters at specific calendar ages a growth curve was constructed for each sex for the age range 8 to 20 years. The values were compared with longitudinal studies of various countries and no substantial differences were found. When VO2 max was then compared to height, body mass and lean body mass it was apparent that the almost linear relationship with height was the most precise. In addition the children remained, generally speaking, in their same rank order for VO2 max for the three different age groupings.
Subject(s)
Physical Fitness , Adolescent , Adult , Body Constitution , Child , Czechoslovakia , Exercise Test , Female , Humans , Male , Oxygen ConsumptionSubject(s)
Germany, East , History, 19th Century , History, 20th Century , Poetry as Topic/history , USSRABSTRACT
Nostalgia (homesickness) was introduced to the domain of medicine only in 1688, but mental suffering corresponding to it was described already in ancient poetry; in Central Europe, it appeared for the first time 700 years ago in the Chronicle of the Zdár monastery, written by Henry the Woodsculptor (= von Heimburg?). In the woodlands between Moravia, Lower Austria and Bohemia, mentioned by Ptolemaios under the Celtic name "Gabreta" (wild goats' wood, cf. Irish "gabrach"), also other behaviour patterns reflecting unusual mental anchorage patterns of the inhabitants appeared between the 13th and 17th centuries. Even if the content of the term "nostalgia" nowadays dissipated to vague "spleen" feelings, its descendant concepts flourish in modern philosophical ("thrownness", "alienation"), psychoanalytical ("existential frustration", "birth trauma," "object loss"), psychiatrical ("agoraphobia", "deprivation", "anaclitic depression") and social psychological ("cataclysmatic fears and anxieties") thought.
