ABSTRACT
Aflatoxina é uma micotoxina que promove importantes efeitos tóxicos na saúde humana e animal, mesmo quando consumida em baixas doses. A administração oral de piperina (2,25mg Kg-1) em frangos de corte, por 14 dias consecutivos, aparentemente interferiu na toxidez da aflatoxina, diminuindo os danos hepáticos e seus efeitos adversos sobre os parâmetros hematológicos característicos da aflatoxicose. Esses dados preliminares sugerem que a piperina poderia ser usada na prevenção dos efeitos tóxicos originados pela ingestão de aflatoxina.
Subject(s)
Animals , Aflatoxins/toxicity , Poisoning/veterinary , Chickens/classification , Aspergillus flavusABSTRACT
Leishmanicidal activity of 6alpha, 7alpha, 15beta, 16beta, 24-pentacetoxy-22alpha-carbometoxy-21beta,22beta-epoxy-18beta-hydroxy-27,30-bisnor-3,4-secofriedela-1,20 (29)-dien-3,4 R-olide (LLD-3 (1)) isolated from Lophanthera lactescens Ducke, a member of the Malpighiaceae, was demonstrated against intramacrophage amastigote forms (IC(50) of 0.41mug/mL). The in vitro leishmanicidal effect of Glucantime, the first choice drug for leishmaniasis treatment, was increased by LLD-3 (1) association. The leishmanicidal effect of LLD-3 (1) was not due to stimulation of nitric oxide production by macrophages. LLD-3 (1) was also not cytotoxic for mouse peritoneal macrophages or B cells as assessed by the XTT and Trypan blue exclusion assays. LLD-3 (1) was unable to affect proliferation of naïve or activated B and T cells, as well as the B cells immunoglobulin synthesis. Cellularity of different tissues, liver and kidney functions were not altered in mice treated with LLD-3 (1), as well as the histology pattern of different organs. Our results add LLD-3 (1) as a potential drug candidate for treatment of leishmaniasis.
