ABSTRACT
Methods of multifactor dispersion analysis of variance of the results of imitation model tests were used to estimate the factors that influence the clonogenic capacity of cells after fractionated irradiation. The "interval between fractions" and "the share of cells at G0" were the major factors at different ratios between radioresistance and efficiency of repair of resting and proliferating cells.
Subject(s)
Clone Cells/radiation effects , Computer Simulation , Models, Biological , Animals , Interphase/radiation effects , Methods , Radiation Tolerance , Time FactorsABSTRACT
The methods of the multifactor disperse analysis of the results of studies of the simulation model of the effect of ionizing radiation on cell populations were used to study the role of some characteristics of the stationary culture in its response to a single radiation effect. The clonogenic capacity of cells was used as a criterion for assessing the biological effect of radiation. "The share of resting cells" was a predominant factor influencing the survival of irradiated cell populations.