Subject(s)
Blood Coagulation , Fibrinolysis , Kinins/biosynthesis , Peritonitis/complications , Shock, Septic/blood , Adolescent , Adult , Humans , Kinins/blood , Middle Aged , Peritonitis/blood , Shock, Septic/etiologySubject(s)
Blood Viscosity , Hemostasis , Thrombophlebitis/blood , Acute Disease , Adult , Aged , Blood Coagulation Disorders/complications , Humans , Middle Aged , Rheology , Thrombophlebitis/etiologySubject(s)
Blood Coagulation , Complement System Proteins/metabolism , Thrombophlebitis/blood , Acute Disease , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
The study of rheological properties of the blood in 115 patients with acute venous thrombosis showed that in 73% of cases haemorheological disorders participate in the pathogenesis of the thrombus formation, in 27% the disease runs a course with the normal rheological characteristics of the blood. The increase of the blood viscosity in venous thrombosis has a multifactorial character and depends on the degree of aggregation of the erythrocytes the cell Z-potential, dys- and hyperproteinaemia. In this respect it is essential to approach the problem differentially to correct haemorheological disturbances and disorders of the coagulation system of the blood in patients with venous thrombosis.
Subject(s)
Blood Viscosity , Thrombophlebitis/etiology , Acute Disease , Adult , Aged , Blood Cell Count , Erythrocyte Aggregation , Humans , Leg/blood supply , Middle Aged , Platelet Aggregation , Rheology , Thrombophlebitis/bloodSubject(s)
Fibrinolytic Agents/administration & dosage , Acute Disease , Blood Coagulation/drug effects , Dextrans/administration & dosage , Drug Evaluation , Drug Therapy, Combination , Heparin/administration & dosage , Humans , In Vitro Techniques , Nicotinic Acids/administration & dosage , Streptokinase/administration & dosage , Thrombophlebitis/drug therapy , Time FactorsSubject(s)
Fibrinolytic Agents/therapeutic use , Streptokinase/therapeutic use , Thrombophlebitis/drug therapy , Acute Disease , Adult , Aged , Dextrans/administration & dosage , Drug Evaluation , Drug Evaluation, Preclinical , Drug Therapy, Combination , Female , Fibrinolytic Agents/administration & dosage , Hemostasis/drug effects , Heparin/administration & dosage , Humans , In Vitro Techniques , Male , Middle Aged , Streptokinase/administration & dosageABSTRACT
Eight-year experience in conducting antithrombotic prophylaxis, by methods elaborated by the authors, in 93 patients operated on for acute thrombosis in the system of venae cavae superior and inferior is generalized. On the basis of the results, the authors advanced the main principle of antithrombotic prophylaxis, the necessity for simultaneous correction of disorders of blood coagulation, fibrinolysis, and aggregation of formed elements of the blood. They showed that the efficacy of postoperative antithrombotic prophylaxis depends on the presence and character of hemodynamic disorders in the involved extremity. It is established that general fractional heparinization is not suitable for antithrombotic prophylaxis due to low efficacy and high rate of hemorrhagic complications. Continuous regional infusion of rheopolyglucin-heparin mixture with nicotinic acid and Trental ensures in most cases correction of the thrombotic condition of hemostasis and effective prevention of rethrombosis of the major veins with minimum hazard of hemorrhagic complications.