Foveal crowding for large and small Landolt Cs: Similarity and Attention.

We compare the recognition of foveal crowded Landolt Cs of two sizes: brief (40 ms), large, low-contrast Cs and high-contrast (1 sec) tests at the resolution limit of the visual system. In different series, the test Landolt C was surrounded by two identical distractors located symmetrically along the horizontal or by a single distractor. The distractors were Landolt Cs or rings. At the resolution limit, the critical spacing was similar in the two series and did not depend on the type of distractor. The result supports the hypothesis that crowding at the resolution limit occurs when both the test and the distractors fall into the same smallest receptive field responsible for the target recognition. For large stimuli, at almost all separations distractors of the same shape caused greater impairment than did rings, and recognition errors were non-random. The critical spacing was equal to 0.5 test diameters only in the presence of one distracting Landolt C. This result suggests that attention is involved: When one distractor is added, involuntary attention, which is directed to the centre of gravity of the stimulus, can lead to confusion of features that are present in both tests and distractors and thus to non-random errors.

A possible mechanism of neural read-out from a molecular engram.

What is the physical basis of declarative memory? The predominant view holds that stored information is embedded in the structure of a neural net, that is, in the signs and weights of its synaptic connections. An alternative possibility is that storage and processing are separated, and that the engram is encoded chemically, most probably in the sequence of a nucleic acid. One deterrent to adoption of the latter hypothesis has been the difficulty of envisaging how neural actively could be converted to and from a molecular code. Our purpose here is limited to suggesting how a molecular sequence could be read out from nucleic acid to neural activity by means of nanopores.

Bongard and Smirnov on the tetrachromacy of extra-foveal vision.

In Moscow in the 1950's, the physicist M. M. Bongard developed the use of silent substitution to establish the number of dimensions of human or animal colour vision and to derive colour-matching functions either for whole organisms or for individual neuronal channels. In 1956, he and his colleague M. S. Smirnov reported that extra-foveal human vision was tetrachromatic when tested by the silent-substitution method that they called 'replacement colorimetry'. In the steady state, trichromatic matches were possible in extra-foveal regions, but transients were visible when one such match was replaced by another. If, however, a match was made with four primaries, then a silent substitution was possible; and such matches - unlike trichromatic ones - were stable with light level and with changes in the state of chromatic adaptation. Bongard and Smirnov believed that the fourth receptor had the spectral sensitivity of the rods, but of course they were working long before the discovery of intrinsically photosensitive retinal ganglion cells. On the fiftieth anniversary of Bongard's grievous death, we provide a translation of Bongard and Smirnov's paper on the tetrachromacy of extra-foveal vision. In a commentary, we give the background to their work and provide further details of their apparatus and procedure. We briefly discuss related research and the reception in the West of Bongard and Smirnov's claims. We suggest that an analogy can be made between the tetrachromacy of the parafovea and the 'weak tetrachromacy' of heterozygotes for anomalous colour vision, whose trichromatic matches are not stable with chromatic adaptation.

How does the human visual system compare the speeds of spatially separated objects?

We measured psychophysical thresholds for discriminating the speeds of two arrays of moving dots. The arrays could be juxtaposed or could be spatially separated by up to 10 degrees of visual angle, eccentricity being held constant. We found that the precision of the judgments varied little with separation. Moreover, the function relating threshold to separation was similar whether the arrays moved in the same, in opposite or in orthogonal directions. And there was no significant difference in threshold whether the two stimuli were initially presented to the same cerebral hemisphere or to opposite ones. How are human observers able to compare stimuli that fall at well separated positions in the visual field? We consider two classes of explanation: (i) Observers' judgments might be based directly on the signals of dedicated 'comparator neurons', i.e. neurons drawing inputs of opposite sign from local regions of the visual field. (ii) Signals about local features might be transmitted to the site of comparison by a shared 'cerebral bus', where the same physical substrate carries different information from moment to moment. The minimal effects of proximity and direction (which might be expected to influence local detectors of relative motion), and the combinatorial explosion in the number of comparator neurons that would be required by (i), lead us to favor models of type (ii).

Discrimination of hue angle and discrimination of colorimetric purity assessed with a common metric.

It has been suggested that thresholds for discriminating colorimetric purity are systematically higher than those for discriminating hue angle, a difference captured in Judd's phrase "the super-importance of hue." However, to compare the two types of discrimination, the measured thresholds must be expressed in the same units. An attractive test is offered by measurements along the horizontal lines in the chromaticity diagram of MacLeod and Boynton [ J. Opt. Soc. Am.69, 1183 (1979)JOSAAH0030-394110.1364/JOSA.69.001183], i.e., a chromaticity diagram. A horizontal line that extends radially from the white point represents a variation in colorimetric purity alone (and subjectively a variation that is primarily in saturation). In contrast, a horizontal line that runs along the $x$x axis of the diagram, close to the long-wave spectrum locus, corresponds predominantly to variation in hue angle. Yet, in both cases, only the ratio of the excitations of the long- and middle-wave cones is being modulated, and so the thresholds can be expressed in a common metric. Measuring forced-choice thresholds for 180 ms foveal targets presented on a steady field metameric to Illuminant D65, we do not find general support for Judd's working rule that thresholds for purity are systematically twice those for saturation. Thresholds for colorimetric purity were only a little higher than those for hue angle, and the advantage for hue was seen in only part of the ranges that were tested. However, in the upper-left quadrant of the MacLeod-Boynton diagram, where the excitation of short-wave cones is high and where both hue angle and colorimetric purity vary along any given horizontal line, thresholds were indeed sometimes half those observed for discrimination of purity alone.

Superior discrimination for hue than for saturation and an explanation in terms of correlated neural noise.

The precision of human colour discrimination depends on the region of colour space in which measurements are made and on the direction in which the compared colours-the discriminanda-differ. Working in a MacLeod-Boynton chromaticity diagram scaled so that thresholds at the white point were equal for the two axes, we made measurements at reference points lying on lines that passed at 45° or -45° through the white point. At a given reference chromaticity, we measured thresholds either for saturation (i.e. for discriminanda lying radially along the line passing through the white point) or for hue (i.e. for discriminanda lying on a tangent of a circle passing through the reference point and centred on the white point). The discriminanda always straddled the reference point in chromaticity. The attraction of this arrangement is that the two thresholds can be expressed in common units. All that differs between saturation and hue measurements is the phase with which the short-wave signal is combined with the long-/middle-wave signal. Except for chromaticities very close to the white point, saturation thresholds were systematically higher than hue thresholds. We offer a possible explanation in terms of correlated neural noise.

Is discrimination enhanced at a category boundary? The case of unique red.

Is chromatic discrimination enhanced at the boundary between different hues? In previous studies, we gave a positive answer for the case of the locus of unique blues and yellows, the boundary that divides color space into reddish and greenish hues. But we did not find enhancement at the locus of unique green, the boundary between yellowish and bluish hues. In the present study, we examined discrimination near the locus of unique red. In interleaved experimental runs, we obtained (1) discrimination thresholds using a four-alternative spatial forced choice and (2) phenomenological judgments of the locus of unique red. When measurements were made along lines parallel to the locus of unique blues and yellows in a MacLeod-Boynton diagram, the locus of minimal thresholds coincided approximately with the locus of unique red; however, this was not the case when measurements were made along lines orthogonal to the locus of unique blues and yellows. To account for these and earlier results, we suppose that the neural channel that determines the discrimination threshold will sometimes coincide with the channel that determines the perceptual hue equilibrium and sometimes will not. If a given point in chromaticity space is a unique hue, then it is expected to remain a unique hue independently of the direction in which measurements are made; however, discrimination thresholds almost certainly will depend on different underlying channels when measurements are made in different directions through the same point in chromaticity space.

[Melatonin in a woman's life: from birth to menopause].

We did a review of the literature data of main Russian publications and databases PubMed/Medline for the last 7 years. In the present article we examine the physiology of secretion of pineal hormone melatonin and its role in the vital processes of the body. The study was focused on the influence of melatonin on the female reproductive system, participation in the aging process and the formation of pathological menopause. The article presents research data on the effectiveness of the drug melatonin in the climacteric syndrome. It is revealed that up to the present time according to the literature data there is no information about the standards of secretion of melatonin for women of different age groups, and the lack of secretion of melatonin can be judged by clinical manifestations, and also when compared with groups of healthy women. Remain unclear issues in the application of drugs melatonin at various complications of pregnancy and gynecological diseases. Long-term use of melatonin is still open in climacteric syndrome.

Is discrimination enhanced at the boundaries of perceptual categories? A negative case.

The human visual system imposes discrete perceptual categories on the continuous input space that is represented by the ratios of excitations of the cones in the retina. Is discrimination enhanced at the boundaries between perceptual hues, in the way that discrimination may be enhanced at the boundaries between speech sounds in hearing? In the chromaticity diagram, the locus of unique green separates colours that appear yellowish from those that appear bluish. Using a two-alternative spatial forced choice and an adapting field equivalent to the Daylight Illuminant D65, we measured chromatic discrimination along lines orthogonal to the locus of unique green. In experimental runs interleaved with these performance measurements, we obtained estimates of the phenomenological boundary from the same observers. No enhancement of objectively measured discrimination was observed at the category boundary between yellowish and bluish hues. Instead, thresholds were minimal at chromaticities where the ratio of long-wave to middle-wave cone excitation was the same as that for the background adapting field.

Symmetries and asymmetries in chromatic discrimination.

Under conditions of adaptation to a steady neutral field (metameric to Daylight Illuminant D65), forced-choice thresholds for color discrimination were measured for brief targets presented to the human fovea. Measurements were made along +45° and -45° lines in a MacLeod-Boynton chromaticity space scaled so that the locus of unique yellow and unique blue lay at -45°. The lines were symmetrical relative to the tritan line passing through the chromaticity of D65. Thresholds increased with distance of the probe chromaticity from D65. Thresholds were higher for saturation discrimination than for hue discrimination. A region of enhanced discrimination was found for thresholds measured orthogonally to the locus of unique blue and unique yellow. There may be an analogous enhancement near the loci of unique red and unique green.

[Estimates of the size of inhibitory areas in crowding effects in periphery].

In psychophysical experiments we studied how surround influences recognition of test objects. The tests were low-contrast Landolt rings of the size 1.1, 1.5 and 2.3 deg. Their centers were located at 13.2 deg from the fixation point. The additional objects were similar Landolt rings or rings without gaps. The distance between the centers of the test and the additional objects varied from 2.2 to 13.2 deg. Inone experiment, the task of the observer was to identify both the test objects and the surrounding objects. In the second experiment the stimulus layout was the same, but'identification of only the test stimulus was required. In both experiments, deterioration of performance was found at all distances between the test objects and the surround, but the deterioration was more significant when the observer carried out the dual task. The data showed that the size of the inhibitory areas in our case does not comply with the Bouma low which states that the size of the interaction areas are equal to half of the eccentricity where the test is presented. Further deterioration of performance in the dual task reveals the contribution of attention into peripheral crowding effects.

Can spatial resolution reveal individual differences in the L:M cone ratio?

We measured spatial resolution in the parafovea for targets designed to isolate either the long-wavelength (L) or the middle-wavelength (M) cones. Landolt C optotypes were presented for 100 ms on a calibrated monitor at an eccentricity of 5° to the left or right of fixation. There were large individual differences in the ratio of the resolution obtained with L targets to that obtained with M targets, and we suggest that these differences reflect variations in the relative sampling densities of L and M cones in the parafovea. In Experiment 1, we measured contrast thresholds for targets of varying size. Among 10 unselected observers, there was a threefold variation in the ratio of the contrast thresholds for the smallest targets. In Experiments 2 and 3, we held contrast constant and we varied size, in order to establish the minimal target that could be discriminated for each of the two classes of cone. In Experiment 2, two groups of observers, selected on the basis of their settings on a flicker-photometric test, showed a highly significant difference in the ratio of the M and L acuities on the spatial task. In Experiment 3, female carriers of protan or deutan deficiencies, classified only on the basis of their sons' phenotypes, also showed a large difference in the ratio of their acuities for M and L targets. In all three experiments, there was a strong correlation between the ratio of M and L spatial acuities and a flicker-photometric measure of relative sensitivity to long- and middle-wavelength light.

[Crowding-effect and attention].

We studied the influence of additional objects on recognition of the test visual objects. The test objects were stylized low-contrast letters having size 1.1, 2.1 or 4.3 ang. deg. The additional objects after 30 ms were followed by the test objects which were presented in the middle of the screen. The additional objects were digits 1-9 having size 1.3 ang. deg. The digits were presented at various distances from the centre of the screen. The observers' task was to identify both the test objects and the digits. Recognition of the test objects deteriorated when the digits were at small distances to the tests (crowding-effect). Recognition of digits deteriorated with the increasing distances from the centre of the screen; the effect was more pronounced when the tests were large. The contribution of laterals masking and attention into crowding-effect is discussed.

Foveal color perception: minimal thresholds at a boundary between perceptual categories.

Human color vision depends on the relative rates at which photons are absorbed by the three classes of retinal cone cell. The ratios of these cone absorptions can be represented in a continuous two-dimensional space, but human perception imposes discrete hue categories on this space. We ask whether discrimination is enhanced at the boundary between color categories, as it is at the boundary between speech sounds. Measuring foveal color discrimination under neutral conditions of adaptation, we find a region of enhanced discrimination in color space that corresponds approximately to the subjective category boundary between reddish and greenish hues. We suggest that these chromaticities are ones at which an opponent neural channel is in equilibrium. This channel would be 'non-cardinal', in that its signals would not correspond to either axis of the MacLeod-Boynton chromaticity diagram.

[Inversion polymorphism in the population of Camptochironomus tentans from Kaliningrad city].

This paper present the map of polytene chromosomes and inversion polymorphism of widely distributed Chironomidae species, Camptochironomus tentans, from the most western locality of Russia--Kaliningrad city. Chromosomes banding pattern is designated according to Beermann, 1955. Only one larva (2.9%) had a standard banding pattern, and karyotypes of the rest (97.1%) were polymorphic. We have found 2.0 heterozygous inversions per individual, and the frequency of hetero- and homozygous inversions, taken together, amounted to 2.2 per individual. 17 inversion banding patterns and 20 genotypic combinations of these patterns were found. It was shown that the most frequent inversions in this population were identical to these in European populations.

[Inversion polymorphism of Glyptotendipes glaucus Mg. (Diptera: Chironomidae) from the reservoirs of Kaliningrad].

The karyotypes of larvae Glyptotendipes glaucus Mg. 1804 from three reservoirs of Kaliningrad city (Pen'kovoe and Karasevka lakes and Chistyi pond) were studied. The levels of the natural inversion polymorphism for the three populations were determined. Ten new inversion sequences (gla B4, gla B5, gla B6, gla D5, gla E4, gla E6, gla E7, gla F6, and gla F7) were detected in the species studied. Inversion including the centromeric region in IIIEF (gla E6 + gla F7) was pericentric. Several cases ofgla B5 and gla B6 combination with gla B2 resulting in genotypic combination gla B2.5 and gla B2.6 were found. The dependence of the number of inversion sequences and genotype combinations from the content of heavy metal ions in sediments of the reservoirs was revealed. All populations were characterized by the prevalence of inversion sequence gla B2 in chromosome I.

The symmetry of visual fields in chromatic discrimination.

Both classical and recent reports suggest a right-hemisphere superiority for color discrimination. Testing highly-trained normal subjects and taking care to eliminate asymmetries from the testing situation, we found no significant differences between left and right hemifields or between upper and lower hemifields. This was the case for both of the cardinal axes of color space. In addition, there was no difference according to whether the discriminanda were delivered to the same or to different hemispheres, and we note that the same number of synapses may lie between the retina and the site of comparison whether or not the stimuli are delivered to the same hemisphere.

[Seasonal variability of the karyotype structure of Chironomus plumosus (Diptera, Chironomidae) from a biotope of Kaliningrad].

Chironomus plumosus larvae from the polluted Shkolnoe lake, Kaliningrad, have 2n = 8 and 2n = 8 + B. In winter season we found 11 types of hetero- and homozygous inversions in A, B, C, D, E, and F arms whereas in summer season we registered 7 types of the same inversions in A, B, C, D, and E arms. All inversions with exception of the inversion in arm C correspond to Hardy-Weinberg equilibrium. The arm IVG shows homozygous increase of centromeric heterochromatin more frequently in summer than in winter (34.4% as compared with 1.8%). The arm E has asynapsis 2 times less frequently in summer than in winter (21.4% as compared with 44.6%).

Central synaptic neurotransmission: universal self-regulation theory.

A prospective randomized study based on case monitoring and treatment of the patients with chronic tension-type headache was carried out, which revealed the regularities in the effects of basic groups of central neurotropic drugs on clinical manifestations and the EEG data. The patients of control (n=90) and experimental (n=91) groups were followed up for 3 months. The experimental group patients were treated with central neurotropic preparations in addition to the routine medicines having peripheral effects. The control group patients received only the routine preparations. The efficiency was assessed by clinical and EEG criteria. The data obtained were analyzed based on fundamental views of modern experimental neurobiology on the gradual nature of postsynaptic responses and their role in universal process of the central neurotransmission. This analysis led to the views on neurochemical origin of EEG rhythms, which has not been yet defined. A theory is advanced, which is based on clinical experience gained in the process of treatment of various functional CNS disorders in more than 5000 patients. This theory makes it possible to use EEG as an objective criterion of efficiency of neurotropic drugs administered to correct central neurotransmission in the patients with clinical pathological functional disorders of CNS.

Detection of narrow bars when presented in the right and left visual hemifields.

Three series of psychophysical experiments were performed to study the effects of additional images on the contrast thresholds for detection of narrow bars of width 1 arc min and length 1 arc degree presented randomly to the left and right sides of the fixation point with an eccentricity of 4 degrees. The additional images were bars of the same size but with lower contrast, presented to the right and left of the test bar at varying distances, i.e., 1-2 degrees. Different series used different contrast ratios for the test and additional bars. The first series revealed significant predominance of one visual hemifield over the other in performing the bar detection task, though the predominant side varied in different subjects. This predominance disappeared or changed to the opposite side in the second or third series. There was a tendency for the additional images to have asymmetrical influences on the detection threshold for the test bar: additional bars had more extensive inhibitory influences when they were on the peripheral side of the test bar. These data provide evidence for the absence of specificity in hemisphere operation in the detection task. The mechanism of description of peripheral images is discussed.