[Effect of lactoferrin on the development of acute and chronic adjuvant arthritis]. / Vliianie laktoferrina na razvitie ostrogo i khronicheskogo ad''iuvantnogo artrita.

An experiment revealed that the therapeutic administration of lactoferrin exerted no effect on the development of early stages of adjuvant arthritis in albino rats during chronicity. This was accompanied by decreased complement consumption and by the lower blood activity of polymorphonuclear leukocytes. The authors consider that this effect is associated with the capacity of lactoferrin to inhibit the excessive proinflammatory activity of neutrophilic leukocytes, which is characteristic of the chronicity of inflammation.

[The status of various indicators of the protease inhibitor system in blood and synovial fluid in rheumatoid arthritis]. / Sostoianie nekotorykh pokazatelei proteazno-ingibitornoi sistemy krovi i sinovial'noi zhidkosti pri revmatoidnom artrite.

Elastase-like activity, alpha 1-inhibitor of proteinases and acid stable antitryptic activity were studied in blood of 26 patients and in synovial fluid of 11 patients with rheumatoid arthritis during acute stage of the disease and after treatment with salase pyridasine and orthophene. The higher values of the elastase-like activity were detected in synovial fluid as compared with that of blood. In blood of these patients, hyperproduction of alpha 1-inhibitor of proteinases and acid stable inhibitors was observed, while deficiency of these substances occurred in synovial fluid. Distinct decrease in the patterns of the blood protease-inhibitory system studied simultaneously with clear positive clinical effect were observed after treatment with salase pyridasine together with orthophene; estimation of these patterns may be used in the evaluation of the therapy.