Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Muscle Nerve ; 54(3): 391-7, 2016 09.
Article in English | MEDLINE | ID: mdl-26840391

ABSTRACT

INTRODUCTION: In this study we investigated whether peripheral nerve sonography could be used as a biomarker to monitor disease progression in amyotrophic lateral sclerosis (ALS). METHODS: In 37 patients, ulnar and median nerve cross-sectional area (CSA) was determined in at least 2 ultrasound sessions; mean follow-up was 14.5 months. Linear mixed-effects models were conducted to analyze time effects on CSA. RESULTS: Ulnar nerve CSA declined significantly at a monthly rate of -0.04 mm(2) (forearm) and -0.05 mm(2) (wrist); the decrease was more pronounced when baseline CSA was greater. To detect a 50% treatment effect on ulnar nerve CSA, 332 patients would need to be entered in a hypothetical randomized, controlled clinical trial. Time had no significant impact on median nerve CSA. CONCLUSIONS: Distal ulnar nerve ultrasound may be a useful biomarker to monitor disease progression in ALS, especially as hypothetical treatment effects on CSA seem to be detectable in manageable cohort sizes. Muscle Nerve 54: 391-397, 2016.


Subject(s)
Amyotrophic Lateral Sclerosis , Peripheral Nerves/diagnostic imaging , Peripheral Nerves/physiopathology , Ultrasonography/methods , Aged , Amyotrophic Lateral Sclerosis/diagnostic imaging , Amyotrophic Lateral Sclerosis/pathology , Amyotrophic Lateral Sclerosis/physiopathology , Disease Progression , Female , Follow-Up Studies , Forearm/innervation , Humans , Male , Middle Aged , Neural Conduction/physiology , Wrist/innervation
2.
Muscle Nerve ; 51(5): 669-75, 2015 May.
Article in English | MEDLINE | ID: mdl-25155020

ABSTRACT

INTRODUCTION: In this study we sought to determine the cross-sectional area (CSA) of peripheral nerves in patients with distinct subtypes of amyotrophic lateral sclerosis (ALS). METHODS: Ulnar and median nerve ultrasound was performed in 78 ALS patients [classic, n = 21; upper motor neuron dominant (UMND), n = 14; lower motor neuron dominant (LMND), n = 20; bulbar, n = 15; primary lateral sclerosis (PLS), n = 8] and 18 matched healthy controls. RESULTS: Compared with controls, ALS patients had significant, distally pronounced reductions of ulnar CSA (forearm/wrist level) across all disease groups, except for PLS. Median nerve CSA (forearm/wrist level) did not differ between controls and ALS. CONCLUSION: Ulnar nerve ultrasound in ALS subgroups revealed significant differences in distal CSA values, which suggests it has value as a marker of LMN involvement. Its potential was particularly evident in the UMND and PLS groups, which can be hard to separate clinically, yet their accurate separation has major prognostic implications.


Subject(s)
Amyotrophic Lateral Sclerosis/diagnostic imaging , Peripheral Nerves/diagnostic imaging , Phenotype , Aged , Amyotrophic Lateral Sclerosis/classification , Case-Control Studies , Female , Humans , Male , Median Nerve/diagnostic imaging , Middle Aged , Muscle, Skeletal/innervation , Ulnar Nerve/diagnostic imaging , Ultrasonography
SELECTION OF CITATIONS
SEARCH DETAIL
...