ABSTRACT
INTRODUCTION AND IMPORTANCE: Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive subtype of squamous cell carcinoma. BSCC in the larynx is an extremely rare occurrence, with only a few cases reported in the medical literature. This case report aims to shed light on the clinical presentation, diagnostic challenges, histopathological features, and therapeutic considerations associated with this rare entity. CASE PRESENTATION: This case report describes a 65-year-old male patient who presented with hoarseness and dyspnea. Laryngoscopy revealed a 2.5 cm pedunculated lesion on the left vocal cord. The patient underwent a laryngectomy, and the histopathological examination of the excised specimen confirmed the diagnosis of BSCC. CLINICAL DISCUSSION: BSCC of the larynx is a rare malignancy comprising less than 1 % of laryngeal cancers. Clinical features often overlap those of squamous cell carcinoma, such as hoarseness, progressive breathing difficulties, and swallowing issues. Treatment approaches vary, with some opting for neo-adjuvant radiotherapy before surgery, like in this case, while others favor surgical excision as the primary treatment, supplemented by adjuvant chemo- or radiotherapy in certain cases. CONCLUSION: Basaloid squamous cell carcinoma is a rare variant of squamous cell carcinoma. Clinicians and pathologists should be aware of the distinctive characteristics of BSCC and its potential clinical aggressiveness. While rare, early recognition and appropriate management are essential for achieving favorable outcomes in patients with this challenging condition.
ABSTRACT
INTRODUCTION AND IMPORTANCE: Primary squamous cell carcinoma of the renal pelvis is a rare malignancy, accounting for fewer than 1 % of all kidney tumors. This form of cancer normally develops in the urinary tract's transitional epithelium, and its presence in the renal pelvis is extremely rare. CASE PRESENTATION: In this report, we discuss the clinical and pathological aspects of a patient with primary squamous cell carcinoma of the renal pelvis. The patient, a 58-year-old man, had flank discomfort associated with burning micturition. A right nephrectomy was done after imaging investigations indicated right kidney hydronephrosis. The diagnosis of primary squamous cell carcinoma was confirmed by pathological investigation of the specimen. The patient has received 4cycles of chemotherapy with cisplatin and gemcitabine. One month later, the patient was referred for a metastatic mass in the chest wall. CLINICAL DISCUSSION: Because of the tumor's rarity, diagnosis and therapy are difficult. This case report emphasizes the significance of including primary squamous cell carcinoma in the differential diagnosis of renal pelvic tumors, especially in individuals with risk factors such as smoking and chronic renal calculi. CONCLUSION: Renal pelvis squamous cell carcinoma is a rare, aggressive, high-grade tumor with a poor prognosis. Chronic irritation plays a substantial role in the process. Thus, patients with a history of urolithiasis should be monitored closely.
