ABSTRACT
Bronchoalveolar lavage using flexible fibreoptic bronchoscope was carried out in 50 patients 1-2 1/2 yr after exposure to the 'toxic gas' at Bhopal. Thirty six patients in the analysis were categorised into 3 groups (viz., mild, moderate and severe), depending upon the severity of exposure. There was an increase in cellularity in the lower respiratory tract (alveolitis) of the severely exposed patients (in both smokers and non-smokers), compared to normals (P less than 0.05). The increase in cellularity in severely exposed non-smokers was due to abnormal accumulation of macrophages (P less than 0.01), and in severely exposed smokers, to macrophages (P less than 0.01) and neutrophils (P less than 0.05). Mild and moderately exposed patients did not show significant change in cellularity in lower respiratory tract, compared to normal individuals (P greater than 0.2). There was a trend towards increasing cellularity, as the severity increased (P less than 0.0001) and higher numbers of total cells were seen in severely exposed smokers, suggesting that smoking is a risk factor. It appears, therefore, that subjects severely exposed to the toxic gas at Bhopal may have a subclinical alveolitis characterised by accumulation and possibly activation of macrophages in the lower respiratory tract. Smokers, who were exposed to the gas had in addition, accumulation of neutrophils.
Subject(s)
Accidents, Occupational , Bronchoalveolar Lavage Fluid/cytology , Cyanates/poisoning , Disasters , Environmental Exposure , Gas Poisoning/complications , Isocyanates , Pulmonary Fibrosis/etiology , Smoking/adverse effects , Adolescent , Adult , Humans , India , Male , Middle Aged , Pulmonary Fibrosis/diagnosisSubject(s)
Accidents, Occupational , Disasters , Gas Poisoning , Isocyanates , Adolescent , Adult , Antibody Formation/drug effects , Child , Chromosome Aberrations/drug effects , Cyanates/poisoning , Female , Gas Poisoning/etiology , Gas Poisoning/genetics , Gas Poisoning/immunology , Humans , Immunity, Cellular/drug effects , India , Male , Middle AgedABSTRACT
Outbreaks of cholera were recorded in Raipur in the years 1970, 1975, 1977 and 1979-1981. Change from V. cholerae classical inaba in 1970 to V. el tor ogawa in 1974 was also observed. The el tor strain is persisting in this area since then. In 1977, antigenic shift to V. el tor inaba was recorded but it again reverted to el tor ogawa which was responsible for outbreaks in 1979-1981. V. cholerae was isolated in most of the months in the years 1975, 1977 and 1980. Almost equal prevalence rates were seen in both sexes as well as in paediatric and adult groups. NAG vibrio were also inoculated. These data suggest endemicity of choloera in Raipur.
