Subject(s)
Blood Platelets/chemistry , Brain Ischemia/etiology , Calcium/analysis , Female , Humans , Male , Middle AgedABSTRACT
A study was made of the distribution of antigens of the isoserological systems ABO, Rh-Hr, MNSs, Duffy, Lutheran, Kidd, Kell-Chellano, P and Lewis in 192 epileptics++ in the Armenian community. It was found that the SS phenotype was significantly positively associated with epilepsy, whereas negative relations were established with the SS and AB phenotypes. The remaining group blood markers cannot serve markers of epilepsy in the Armenian community. The segregation familial analysis demonstrated as well that the MNSs system is not related genetically to the HLA system and the gene of "predisposition" to epilepsy, coupled in the Armenian community with HLA-B27 (cross-B27) and HLA-DR3 antigens.
Subject(s)
Blood Group Antigens/genetics , Epilepsy/etiology , Erythrocytes/immunology , HLA-B27 Antigen/genetics , HLA-DR3 Antigen/genetics , Armenia , Disease Susceptibility , Epilepsy/blood , Epilepsy/genetics , Epilepsy/immunology , Genetic Markers/genetics , Genetic Markers/immunology , Haplotypes/genetics , Humans , PhenotypeABSTRACT
The isoserologic systems, including AB, Rh-Hz, MNSs, Duffy, Kidd, Kell-Chellano, Lutheran, Diego, and Lewis ones were investigated in 50 patients with disseminated sclerosis and in the general population. An increased rate of the Duffy phenotype (a-b+) is reported in the patients versus the population control. Individuals with this phenotype are at three times as great a risk of developing disseminated sclerosis than those with the Duffy phenotype (a+b-). The Duffy antigen (b+) is considered as a possible genetic marker of the disease in the Armenian population.