ABSTRACT
To evaluate the cicatrization of the uterine horn after the recanalization by endoluminal laser probe, 50 white female rats of Wistar's race have been separated into two groups. The group 1 (nb = 10) had for aim to validated the procedure of obstruction. In group 2 (nb = 40), we performed the recanalization six weeks after the obstruction. Histologic samples were obtained 48 hours, 3 weeks and 6 weeks after treatment. In group 1, we found a complete obstruction in 70% of the cases, and a tight stenosis in 30% of the cases. In group 2, at 48 hour's control after the treatment by laser, we found a drill hole with a blackened look without parietal sequel in 80% of the cases. At 6 week's control, we found a normal lumen with a regeneration of the epithelioma in 85% of the cases. For energy deposition under 30 Joules, we found good results in 95% of the cases. Above 30 Joules, we always found bad results (5 cases on 5).
Subject(s)
Cicatrix/etiology , Fallopian Tube Diseases/surgery , Laser Therapy/adverse effects , Postoperative Complications/etiology , Animals , Cicatrix/epidemiology , Cicatrix/pathology , Evaluation Studies as Topic , Female , Laser Therapy/instrumentation , Laser Therapy/methods , Postoperative Complications/epidemiology , Postoperative Complications/pathology , Rats , Rats, Inbred Strains , Wound HealingABSTRACT
To evaluate the function of the fallopian tube after a recanalization by endoluminal laser probe, 34 mature female New Zealand white rabbits have been separated into two groups. The group 1 (nb = 12) had for aim to validate the procedure of obstruction. In group 2 (nb = 22), we performed the recanalization six weeks after the obstruction. The female rabbits underwent a fertilization six weeks after the laser treatment. The results have been appreciated by the ratio nidation/ovulation. In group 1, we valided the procedure of obstruction. In group 2 twelve rabbits on thirteen have been fecundated in the treated tube.
Subject(s)
Fallopian Tube Diseases/surgery , Fertility , Laser Therapy/standards , Animals , Disease Models, Animal , Evaluation Studies as Topic , Fallopian Tube Diseases/pathology , Fallopian Tube Diseases/physiopathology , Female , Laser Therapy/instrumentation , Laser Therapy/methods , RabbitsABSTRACT
A fiber-optic tip catheter has been developed for treating coronary and peripheral atherosclerosis percutaneously. The catheter is coupled to an ionised Argon laser emitting at an optical power of 1 to 7 Watts. It is designed to follow a guide wire and to perform tissue ablation by a new concept combining the effects of central vaporisation and peripheral thermal remodelling of the obstructed artery. This mode of function should considerably reduce the risks of false route previously encountered with laser angioplasty. The optical and thermic properties of the catheter prototypes were determined by physical methods. These experiments showed that the temperature of the metallic component of the catheter tip did not exceed 30 degrees C at a continuous power of 6 laser Watts when the flush was functioning. It attained 400 degrees C in the absence of the flush. The performances of the catheter were then tested in a number of in vitro experiments. First of all, the catheter tip was placed perpendicularly to atheromatous cadaver aortae to study the effect of vaporisation with respect to the laser power. The threshold of vaporisation was 1 Watt (irradiance: 1100 Watts/cm2). The catheter was then introduced into plastic tubes obstructed by atheromatous plaques. This experiment demonstrated the mechanical solidity of the catheter and its flexibility in difficult operating conditions: diameter 2mm, 45 degrees angles, irregular calcified plaques. It also showed that the optimal safety-efficacy laser power was 3 laser Watts and that the exposure times varied with respect to the nature of the plaques tested.(ABSTRACT TRUNCATED AT 250 WORDS)
