1.
Arch Pharm (Weinheim)
; 334(2): 53-61, 2001 Feb.
Article
in English
| MEDLINE
| ID: mdl-11268775
ABSTRACT
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-alpha production in the plasma in comparison with that of cabenegrin A-I (1a).
Subject(s)
Benzene Derivatives/chemical synthesis , Benzopyrans/chemical synthesis , Benzopyrans/pharmacology , Butanols/chemical synthesis , Lipopolysaccharides/antagonists & inhibitors , Tumor Necrosis Factor-alpha/biosynthesis , Animals , Benzene Derivatives/chemistry , Benzene Derivatives/pharmacology , Benzopyrans/chemistry , Butanols/chemistry , Butanols/pharmacology , Male , Mice , Mice, Inbred BALB C , Structure-Activity Relationship
2.
J Med Chem
; 14(6): 527-8, 1971 Jun.
Article
in English
| MEDLINE
| ID: mdl-5091968
