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Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.
Bouzouita, Imen; Cabibbe, Andrea Maurizio; Trovato, Alberto; Daroui, Henda; Ghariani, Asma; Midouni, Basma; Essalah, Leila; Mehiri, Emna; Cirillo, Daniela Maria; Saidi, Leila Slim.
Emerg Infect Dis ; 25(3): 538-546, 2019 03.
Article in English | MEDLINE | ID: mdl-30789128

ABSTRACT

To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012-2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions.


Subject(s)
Drug Resistance, Multiple, Bacterial , Genome, Bacterial , Mycobacterium tuberculosis/drug effects , Mycobacterium tuberculosis/genetics , Tuberculosis, Multidrug-Resistant/epidemiology , Tuberculosis, Multidrug-Resistant/microbiology , Whole Genome Sequencing , Adult , Female , Genes, Bacterial , History, 21st Century , Humans , Male , Middle Aged , Mutation , Mycobacterium tuberculosis/classification , Phylogeny , Public Health Surveillance , Retrospective Studies , Tuberculosis, Multidrug-Resistant/history , Tunisia/epidemiology , Young Adult
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