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1.

Pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum.

Krueger, G R; Graw, R G; Rogentine, G N; Darrow, C C; Neefe, J R; Luetzeler, J.

Blut ; 30(1): 19-30, 1975 Jan.

Article in English | MEDLINE | ID: mdl-234261

ABSTRACT

Lethally irradiated rhesus monkeys were used for bone marrow allografting and autografting. Monkeys receiving allogeneic bone marrow developed acute graft-versus-host reaction (GVHR) and had a mean survival time of 9.1 days as compared to autografted monkeys which survived above 500 days. Treatment with antilymphocyte sera (ALS) before allografting modified the GVHR and extended the survival time to an average of 43 days. Histologically, such animals showed evidence of "chronic" GVHR and septicemia secondary to a lack in lymphoreticular recovery. Subsequently, severe GI-tract infections followed which usually served as portal of entry for septicemia.

Subject(s)

Antilymphocyte Serum/therapeutic use , Bone Marrow Cells , Bone Marrow Transplantation , Graft vs Host Reaction , Radiation Injuries, Experimental , Animals , Immunosuppression Therapy , Intestinal Mucosa/pathology , Jejunum/pathology , Liver/pathology , Lymph Nodes/pathology , Macaca , Pulmonary Veins/pathology , Time Factors , Transplantation, Autologous , Transplantation, Homologous

2.

Beneficial influence of limited histocompatibility of bone marrow grafted to unrelated rhesus monkeys preconditioned with x-ray and ALS.

Neffe, J R; Merritt, C B; Darrow, C C; Rogentine, G N.

Transplant Proc ; 6(2): 125-8, 1974 Jun.

Article in English | MEDLINE | ID: mdl-4208750

Subject(s)

Antilymphocyte Serum/pharmacology , Bone Marrow Cells , Bone Marrow Transplantation , Histocompatibility/radiation effects , Radiation Effects , Animals , Graft vs Host Disease/immunology , Haplorhini , Histocompatibility/drug effects , Histocompatibility Antigens/analysis , Histocompatibility Testing , Horses/immunology , Macaca , Rabbits/immunology , Radiation Chimera , Transplantation, Homologous

3.

Spontaneous neoplasms of nonhuman primates. Attempted transmission to immunosuppressed hosts and in vitro characterization.

Cicmanec, J L; Neubauer, R H; Wallen, W C; Darrow, C C; Rabin, H.

Lab Anim Sci ; 24(1): 233-4, 1974 Feb.

Article in English | MEDLINE | ID: mdl-4360751

Subject(s)

Immunosuppression Therapy , Monkey Diseases/immunology , Neoplasms/veterinary , Adrenal Gland Neoplasms/veterinary , Animals , Antilymphocyte Serum/administration & dosage , Carcinoma/immunology , Carcinoma/microbiology , Carcinoma/veterinary , Female , Haplorhini , Leukemia, Myeloid/immunology , Leukemia, Myeloid/microbiology , Leukemia, Myeloid/veterinary , Macaca , Male , Monkey Diseases/microbiology , Neoplasm Metastasis , Neoplasm Transplantation , Retroviridae/isolation & purification , Transplantation, Homologous

4.

Histocompatibility and bone marrow transplantation between unrelated rhesus monkeys.

Neefe, J R; Merritt, C B; Vaal, L; Darrow, C C; Rogentine, G N.

Transplantation ; 16(4): 365-70, 1973 Oct.

Article in English | MEDLINE | ID: mdl-4126789

Subject(s)

Bone Marrow Cells , Bone Marrow Transplantation , Histocompatibility , Macaca/immunology , Animals , Antigens , Antilymphocyte Serum , Graft vs Host Reaction , Haplorhini , Histocompatibility Antigens , Horses/immunology , Lymphocytes/immunology , Rabbits , Radiation Chimera , Rh-Hr Blood-Group System , Skin Transplantation , Time Factors , Transplantation, Homologous , gamma-Globulins

5.

Mixed lymphocyte reactivity in rhesus sibships.

Neefe, J R; Vaal, L; Darrow, C C; Rogentine, G N.

Transplantation ; 15(5): 507-10, 1973 May.

Article in English | MEDLINE | ID: mdl-4196992

Subject(s)

Histocompatibility Testing , Isoantigens/isolation & purification , Lymphocyte Activation , Animals , Haplorhini , Macaca

6.

Rescue of rhesus monkeys from acute lethal graft-versus-host disease using cyclophosphamide and frozen autologous bone marrow.

Merritt, C B; Darrow, C C; Vaal, L; Herzig, G P; Rogentine, G N.

Transplantation ; 15(1): 154-9, 1973 Jan.

Article in English | MEDLINE | ID: mdl-4145721

Subject(s)

Bone Marrow Cells , Bone Marrow Transplantation , Cyclophosphamide/therapeutic use , Disease Models, Animal/immunology , Graft vs Host Disease/immunology , Graft vs Host Reaction , Macaca/immunology , Transplantation Immunology , Animals , Blood Platelets/immunology , Bone Marrow/immunology , Bone Marrow/radiation effects , Cyclophosphamide/administration & dosage , Freezing , Graft vs Host Disease/drug therapy , Graft vs Host Disease/prevention & control , Graft vs Host Reaction/radiation effects , Haplorhini , Leukocytes/immunology , Radiation Effects , Reticulocytes/immunology , Time Factors , Transplantation, Homologous

7.

Methods of anesthesia in nonhuman primates.

Martin, D P; Darrow, C C; Valerio, D A; Leiseca, S A.

Lab Anim Sci ; 22(6): 837-43, 1972 Dec.

Article in English | MEDLINE | ID: mdl-4345303

Subject(s)

Anesthesia/veterinary , Primates , Anesthesia, General , Anesthesia, Inhalation , Animals , Atropine/administration & dosage , Benperidol , Body Temperature , Fentanyl , Halothane , Haplorhini , Infusions, Parenteral , Intubation, Intratracheal , Ketamine , Macaca , Pan troglodytes , Papio , Phencyclidine , Salivation/drug effects , Thiamylal , Thiopental , Tranquilizing Agents

8.

Rhesus lymphocyte alloantigens. II. Serologic, genetic, and chemical characteristics.

Rogentine, G N; Merritt, C B; Vaal, L A; Ellis, E B; Darrow, C C.

Transplant Proc ; 4(1): 21-31, 1972 Mar.

Article in English | MEDLINE | ID: mdl-4110959

Subject(s)

Isoantigens/analysis , Lymphocytes/immunology , Amino Acid Sequence , Amino Acids/analysis , Animals , Chromium Isotopes , Cytotoxicity Tests, Immunologic , Electrophoresis, Disc , Epitopes , Genotype , Haplorhini , Histocompatibility , Leukocytes/immunology , Macaca , Papain/pharmacology , Phenotype , Skin Transplantation , Spleen/cytology , Spleen/immunology

9.

Joint report of first histocompatibility workshop on primates.

Balner, H; Barnes, A D; D'Amaro, J; Darrow, C C; Démant, P; Gabb, B W; Piazza, A; Metzgar, R S; Seigler, H F; Rogentine, G N; van Rood, J J; Ward, F; Zweerus, R L.

Transplant Proc ; 4(1): 141-7, 1972 Mar.

Article in English | MEDLINE | ID: mdl-4622176

Subject(s)

Histocompatibility , Isoantigens , Primates/immunology , Terminology as Topic , Animals , Blood Group Antigens , Erythrocytes/immunology , Haplorhini , International Cooperation , Macaca , Pan troglodytes

10.

Rhesus lymphocyte alloantigens. I. Identification of a major alloantigen system.

Rogentine, G N; Vaal, L; Ellis, E B; Darrow, C C.

Transplantation ; 12(4): 267-70, 1971 Oct.

Article in English | MEDLINE | ID: mdl-5000332

Subject(s)

Antigens , Lymphocytes/immunology , Transplantation Immunology , Alleles , Animals , Antigens, Heterophile , Bone Marrow Transplantation , Cytotoxicity Tests, Immunologic , Haplorhini , Histocompatibility , Transplantation, Homologous

11.

Prolonged rhesus skin allograft survival produced by antihuman thymocyte serum.

Darrow, C C; LaFontaine, G S; Smith, J J; Martin, D P; Sell, K W; Kayhoe, D E.

Transplant Proc ; 3(1): 730-2, 1971 Mar.

Article in English | MEDLINE | ID: mdl-4999466

Subject(s)

Antilymphocyte Serum/administration & dosage , Skin Transplantation , Transplantation Immunology , Animals , Haplorhini , Histocompatibility , Immunodiffusion , Methods , Transplantation, Homologous

12.

Rearing of infant simians in modified germfree isolators for oncogenic studies.

Valerio, D A; Darrow, C C; Martin, D P.

Lab Anim Care ; 20(4 Pt 1): 713-9, 1970 Aug.

Article in English | MEDLINE | ID: mdl-4247967

Subject(s)

Germ-Free Life , Haplorhini/growth & development , Oncogenic Viruses , Animals , Animals, Laboratory , Animals, Newborn , Birth Weight , Breeding , Diarrhea/veterinary , Digestive System/microbiology , Enteritis/veterinary , Escherichia coli Infections/veterinary , Female , Male , Monitoring, Physiologic , Pneumonia/microbiology , Pneumonia/veterinary , Proteus Infections/veterinary , Pseudomonas/isolation & purification , Pseudomonas Infections/veterinary , Research , Staphylococcus/isolation & purification

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