1.
ACS Med Chem Lett
; 15(7): 1118-1126, 2024 Jul 11.
Article
in English
| MEDLINE
| ID: mdl-39015282
ABSTRACT
This study investigates the impact of C70 and C60 fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids Q 3 C 70 M and Q 3 C 60 M exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. Q 3 C 60 M enhances apoptosis, while Q 3 C 70 M reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. Q 3 C 70 M demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating BAX and BCL-2 levels. This innovative approach, distinguishing between C70 and C60, represents a novel contribution to the existing scientific literature.