Pioneering the Photoactive Relevance of Quinazolinone-Fullereropyrrolidine Nanohybrids To Address Chemotherapeutic Resistance in Cancer.

This study investigates the impact of C70 and C60 fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids Q 3 C 70 M and Q 3 C 60 M exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. Q 3 C 60 M enhances apoptosis, while Q 3 C 70 M reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. Q 3 C 70 M demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating BAX and BCL-2 levels. This innovative approach, distinguishing between C70 and C60, represents a novel contribution to the existing scientific literature.