ABSTRACT
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition portrayed by persistent airflow limitation and correlated symptoms. Despite advances in treatment, COPD remains a significant global health burden, necessitating ongoing research to understand its long-standing impact on pulmonary function and quality of life (QoL). Methods: This longitudinal research enrolled 200 COPD and followed them over a 5-year period. Baseline assessments included spirometry to measure forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), along with standardized questionnaires assessing QoL. Follow-up assessments were conducted annually, and statistical analysis was performed to examine changes in pulmonary function and QoL over time. Results: Significant declines in FEV1 and FVC were observed at each follow-up time point compared to the baseline, indicating progressive deterioration in lung function. QoL scores, as assessed by the St. George's Respiratory Questionnaire and the COPD Assessment Test, also worsened progressively over the research period. Conclusion: Current conclusions underscore the progressive nature of COPD, highlighting the importance of proactive management strategies aimed at preserving lung function and improving QoL. Early intervention and ongoing monitoring are essential in optimizing outcomes for COPD subjects and reducing the disease burden on individuals and healthcare systems.