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Biomater Sci ; 7(4): 1281-1285, 2019 Mar 26.
Article in English | MEDLINE | ID: mdl-30735211

ABSTRACT

In this communication we report that anchoring αvß3 or α5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.


Subject(s)
Biocompatible Materials/pharmacology , Bone and Bones/drug effects , Mesenchymal Stem Cells/drug effects , Oligopeptides/pharmacology , Peptidomimetics/pharmacology , Animals , Biocompatible Materials/chemical synthesis , Biocompatible Materials/chemistry , Bone Regeneration/drug effects , Integrin alpha5beta1/chemistry , Integrin alphaVbeta3/chemistry , Ligands , Molecular Structure , Oligopeptides/chemical synthesis , Oligopeptides/chemistry , Peptidomimetics/chemistry , Rats , Titanium/chemistry , Titanium/pharmacology , Wound Healing/drug effects
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