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Biomed Khim ; 55(3): 247-54, 2009.
Article in Russian | MEDLINE | ID: mdl-19663000

ABSTRACT

Application of blood plasma metabolites fingerprinting for the diagnostic of the 2nd stage of prostate cancer has been investigated. The diagnostic sensitivity (95%), specificity (96.7%) and accuracy (95.7%) of the metabolic fingerprinting were much higher then those for PSA test (35%, 83.3% and 51.7%, respectively) for the same patients. Area under the ROC-curve (0.994) suggests that the proposed approach is effective and can be used for clinical applications.


Subject(s)
Biomarkers, Tumor/blood , Blood Proteins/analysis , Prostatic Neoplasms/blood , Humans , Male , Metabolome , Prostatic Neoplasms/diagnosis , ROC Curve , Spectrometry, Mass, Electrospray Ionization
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