ABSTRACT
Doxazosin (mean dose 11 mg) given once daily in combination with 100 mg atenolol (n = 44) was compared with placebo and atenolol (n = 43) in a double-blind, multicenter study in patients with mild to moderate essential hypertension. In the atenolol/doxazosin-treated group, standing blood pressure significantly decreased by 17.0/12.3 mm Hg compared to 6.2/6.7 mm Hg in the atenolol/placebo group whereas supine blood pressure decreased by 13.2/9.8 mm Hg and 9.2/6.0 mm Hg, respectively in the two groups. Serum lipids did not change significantly in either group. The majority of side-effects reported were mild and transient. This study confirms that doxazosin may be safely combined with a beta-blocker. Doxazosin proved to be well tolerated and effective in patients with blood pressure refractory to atenolol alone.
Subject(s)
Antihypertensive Agents/therapeutic use , Atenolol/therapeutic use , Hypertension/drug therapy , Prazosin/analogs & derivatives , Adolescent , Adult , Aged , Antihypertensive Agents/administration & dosage , Atenolol/administration & dosage , Blood Pressure/drug effects , Double-Blind Method , Doxazosin , Drug Therapy, Combination , Humans , Middle Aged , Prazosin/administration & dosage , Prazosin/therapeutic useABSTRACT
Acute renal failure may occur in the nephrotic syndrome due to minor glomerular changes, especially in the elderly. We describe five cases and review the literature. Previous renal damage due to ischaemia and drugs may be important in pathogenesis. We stress the importance of active management of these cases, as the renal lesions are reversible and recovery can be expected.
