1.
Bioorg Med Chem Lett
; 16(3): 746-9, 2006 Feb.
Article
in English
| MEDLINE
| ID: mdl-16321528
ABSTRACT
The SAR of the lead compound 3, a novel ligand for the alpha(2)delta subunit of voltage-gated calcium channels, was rapidly explored. Utilizing a parallel solution-phase Sn2Ar coupling approach, a focused library was obtained. The library was evaluated in vitro and afforded a series of analogues with improved potencies. The SAR trends of the library are also described.