ABSTRACT
Mesoporous silica nanoparticles (MSNs) exhibit unique drug delivery properties and are thus considered as promising candidates for next generation nano-medicines. In particular, inhalation into the lungs represents a direct, non-invasive delivery route for treating lung disease. To assess MSN biocompatibility in the lung, we investigated the bioresponse of avidin-coated MSNs (MSN-AVI), as well as aminated (uncoated) MSNs, after direct application into the lungs of mice. We quantified MSN distribution, clearance rate, cell-specific uptake, and inflammatory responses to MSNs within one week after instillation. We show that amine-functionalized (MSN-NH2) particles are not taken up by lung epithelial cells, but induced a prolonged inflammatory response in the lung and macrophage cell death. In contrast, MSN-AVI co-localized with alveolar epithelial type 1 and type 2 cells in the lung in the absence of sustained inflammatory responses or cell death, and showed preferential epithelial cell uptake in in vitro co-cultures. Further, MSN-AVI particles demonstrated uniform particle distribution in mouse lungs and slow clearance rates. Thus, we provide evidence that avidin functionalized MSNs (MSN-AVI) have the potential to serve as versatile biocompatible drug carriers for lung-specific drug delivery.
Subject(s)
Drug Carriers/chemistry , Lung/drug effects , Lung/metabolism , Nanoparticles , Animals , Avidin , Cell Line , Coculture Techniques , Cytokines/metabolism , Drug Delivery Systems , Epithelial Cells/drug effects , Epithelial Cells/metabolism , Female , Inflammation Mediators/metabolism , Lung/cytology , Macrophages, Alveolar/drug effects , Macrophages, Alveolar/metabolism , Mice , Mice, Inbred BALB C , Nanomedicine , Nanoparticles/administration & dosage , Nanoparticles/chemistry , Nanoparticles/toxicity , Silicon DioxideABSTRACT
A novel thermoresponsive snaptop for stimulated cargo release from superparamagnetic iron oxide core - mesoporous silica shell nanoparticles based on a [2 + 4] cycloreversion reaction (retro-Diels Alder reaction) is presented. The non-invasive external actuation through alternating magnetic fields makes this material a promising candidate for future applications in externally triggered drug delivery.
ABSTRACT
A strong increase of inclusive nuclear-charge pickup cross sections, forming 83Bi from 158A GeV 82Pb ions, is observed in comparison to similar measurements at 10.6A GeV. From the dependence of these cross sections on target atomic number, this increase is attributed to the electromagnetic process of pion production by equivalent photons. The observed cross sections can be reproduced quantitatively using the recently developed RELDIS code.
ABSTRACT
We report on the first experiment that measures simultaneously the full momentum vector of recoil ions and projectile energy loss and scattering angle in ion-atom collisions. We studied multiple ionization in the collisions of 0.83-MeV/u O7+ with Ne. Recoil ions ( Ne(q+), q = 1-8) were detected in coincidence with single capture to O6+. The results give the first experimental evidence for the increase of the average electron energy with increasing recoil charge state q. The average ejection angle shows a dramatic decrease with q. Results are compared with n-electron classical trajectory Monte Carlo calculations.
ABSTRACT
To better understand the propensity for the three-body breakup in dissociative recombination (DR) of dihydrides ( H(3)(+), NH(2)(+), CH(2)(+), and H(2)O(+)), we undertook a study of the dynamics of this process. A study of DR of H(2)O(+) to give O + H + H was carried out at the CRYRING Heavy-Ion Storage Ring in Stockholm. With the stored beam energy of 4.5 MeV, we separated the O signal from the H signals with a differential absorber, thus reducing the problem to a sum of two two-body problems. Results included (1) the ratio of O((3)P) to O((1)D) product, (2) the distribution of recoil-kinetic energy between the two hydrogen atoms, (3) the angular distribution between the hydrogen atoms in the O((3)P) channel and in the O((1)D) channel.
ABSTRACT
Knowledge of the abundance of H(3)(+) is needed in interstellar and planetary atmospheric chemistry. An important destruction mechanism of H(3)(+) is low-energy electron impact followed by dissociation, but estimates of the reaction rate span several orders of magnitude. As an attempt to resolve this uncertainty, the cross section for dissociative recombination of vibrationally cold H(3)(+) has been measured with an ion storage ring down to collision energies below 1 millielectron volt. A rate coefficient of 1.15 x 10(-7) cubic centimeters per second at 300 kelvin was deduced. The cross section scaled with collision energy according to E(-1.15), giving thee rate a temperature dependence of T(-0.65).
