ABSTRACT
Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and ß-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with ß-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with ß-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with ß-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results.
ABSTRACT
A 42-year-old man presented as an emergency to the ENT department with sore throat and complete dysphagia, having undergone an umbilical hernia repair under general anaesthesia with tracheal intubation 3 weeks previously at another institution. One course of antibiotics from his general practitioner improved the symptoms but, on discontinuation of the antibiotics, symptoms flared up leading to complete dysphagia. Indirect laryngoscopy showed a bulging of the retropharyngeal wall, which was confirmed as a widening of the retropharyngeal space on a lateral soft-tissue X-ray film of the neck. Surgical exploration confirmed a retropharyngeal abscess, which probably occurred as a complication of the original tracheal intubation.
Subject(s)
Intubation, Intratracheal/adverse effects , Retropharyngeal Abscess/etiology , Adult , Anesthesia, General , Hernia, Umbilical/surgery , Humans , Male , Retropharyngeal Abscess/diagnosis , Retropharyngeal Abscess/therapyABSTRACT
We report a 10-year-old boy who presented with a piece of chicken stuck in his throat. He had similar episodes in the past that resolved spontaneously. The foreign body was removed and oesophagoscopy revealed no abnormality. Post-operative barium swallow showed oesophageal intramural pseudodiverticulosis.
Subject(s)
Deglutition Disorders/etiology , Diverticulum, Esophageal/diagnosis , Foreign Bodies , Barium , Child , Diverticulum, Esophageal/complications , Diverticulum, Esophageal/therapy , Esophageal Stenosis , Esophagitis , Esophagoscopy , Humans , MaleABSTRACT
The term sialectasis refers to dilation of the salivary ducts. Parotid sialectasis presents itself as recurrent painful swellings during mastication and/or swallowing. Our results with 10 cases treated by tympanic neurectomy over a period of nine years, from 1983 to 1992, were encouraging as seven cases had improvement of their symptoms. Anatomy of the tympanic plexus and surgical procedure are discussed as well as a review of the literature. We recommend extensive interruption of the secreto-motor nerve fibers by thoroughly drilling into the hypotympanum and below the basal turn of the cochlea. We also recommend that this be carried out by an experienced otologist to avoid possible complications.
