ABSTRACT
Cardiac sarcoidosis is a disease of young adults. In most cases it presents with sudden death, arrhythmias, conduction disorders, heart failure or cardiomyopathy. The authors describe two cases of myocardial involvement by sarcoidosis that lead to death of the patients. Case one was a 26-year-old Indian man who was previously well and presented with sudden death. Autopsy showed nodules of sarcoid granuloma involving the heart, lungs and lymph nodes. Case two was a 47-year-old Indian lady who complained of reduced effort tolerance. Echocardiography showed that she had restrictive hypertrophic cardiomyopathy with heart failure. Seven months after initial presentation, she developed worsening of heart failure and died. Autopsy revealed involvement of the heart, lungs and liver by sarcoidosis.
Subject(s)
Cardiomyopathies/diagnosis , Sarcoidosis/diagnosis , Adult , Angiography , Autopsy , Cardiomegaly/pathology , Cardiomyopathies/pathology , Death, Sudden, Cardiac , Electrocardiography, Ambulatory , Fatal Outcome , Female , Granuloma/pathology , Humans , Hypertrophy, Left Ventricular/pathology , India/ethnology , Male , Middle Aged , Myocardium/pathology , Sarcoidosis/diagnostic imaging , Sarcoidosis/ethnology , Sarcoidosis/pathologyABSTRACT
A 46-year-old Indian man was admitted with unstable angina (Braunwald's class IIIB1)--the chest pain at rest was associated with inferolateral ischaemia on the ECG at admission. His serial total creatine kinase levels were elevated but CKMB was not detected. Serial serum troponin T levels were significantly raised suggesting the presence of significant acute myocardial injury.
