Candida Glabrata Lymphadenitis Following Infliximab Therapy for Inflammatory Bowel Disease in a Patient With Chronic Granulomatous Disease: Case Report and Literature Review.

Chronic granulomatous disease (CGD) is an inborn error of immunity caused by inactivating genetic mutations in any one of the components of the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Phagocytic cell reactive oxygen species generation is impaired in the absence of a functional NADPH oxidase complex. As a result, patients with CGD are at high risk of developing deep-seated infections with certain bacteria and fungi. Additionally, aberrant inflammation and granuloma formation may occur in multiple organs including the bowels, with inflammatory bowel disease seen as a common inflammatory complication of CGD. Traditionally, TNF-α inhibitors are considered effective biological therapies for moderate-to-severe inflammatory bowel disease. While limited case series and reports of patients with CGD have shown improvement in fistula healing with use of TNF-α inhibitors, several patients have developed severe, even fatal, infections with CGD-related pathogens while on TNF-inhibitor therapy. In this case report, we describe an adolescent male with X-linked CGD and steroid-refractory colitis with perirectal fistula and abscesses, who was initiated on treatment with infliximab, a TNF-α inhibitor. Following his first two infliximab doses, the patient developed a Candida glabrata lymphadenitis and associated ulcerating oropharyngeal lesions, requiring hospitalization and therapy with amphotericin B for resolution. We compare our patient's case to prior reports of infliximab use in CGD-related inflammatory bowel disease.

International patients in a Turkish hospital: a quantitative study on cross-border health care at the intersection of Eastern Europe, Asia and the Middle East.

This is the first attempt, to our knowledge, that aims to empirically quantify and characterize international patient flows to Turkey. A cross-sectional retrospective study was performed on consecutive patients seen at the International Services Department of a 209-bed private hospital in urban Turkey. Over six months, international patients represented 4 percent and 6 percent of all consultations and surgical procedures, respectively. Six hundred and fifty unique international patients received health care and represented 44 different countries. Among these 650 unique encounters, most patients originated from Bulgaria (37%), Romania (35%), Azerbaijan (6%), Iraq (3%) and Georgia (3%). International patients commonly required oncological (54%), surgical (13%) and neurological (7%) services. Although quantitative data on medical travel to Turkey is limited, significant patient flows exist from neighboring countries to Turkey.