ABSTRACT
The aim of this study was to identify differences in bone shape (height and width) of proximal sesamoid bones (PSB) in 2-year-old Thoroughbred racehorses in training. Dorsal 15° proximal-palmarodistal oblique images of each metacarpophalangeal joint were acquired before the horses started training and at 1 year after the start of exercise and racing. There were no changes in height and width of PSBs induced by training. There was a significant difference of height and width between medial and lateral PSBs. In both forelimbs, the medial PSB was significantly wider and shorter than the lateral PSB. The medial PSB of the right forelimb was significantly wider than that of the left forelimb. These results might explain some limb predilection for fracture of PSBs. The difference in strain pattern between medial and lateral PSBs in different loading conditions needs to be investigated.
Subject(s)
Horses/anatomy & histology , Metacarpophalangeal Joint/anatomy & histology , Physical Conditioning, Animal , Sesamoid Bones/anatomy & histology , Stress, Physiological , Animals , Forelimb/anatomy & histology , Forelimb/diagnostic imaging , Metacarpophalangeal Joint/diagnostic imaging , Radiography , Running/physiology , Sesamoid Bones/diagnostic imagingSubject(s)
Odontogenic Cysts/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Odontogenic Cysts/classification , Odontogenic Cysts/pathologyABSTRACT
The platelet aggregate filtration pressure test (PAFP) was used to study the aggregant activity of single doses of 200 mg indobufen, administered either orally or by i.v. injection. This double-blind study using placebo in a crossover design was conducted in twelve patients whose baseline aggregation values were high. The compound showed markedly different antiaggregant activity from placebo at the various observation times after administration. The two administration routes did not produce any significant differences. The PAFP test can be useful in identifying atherosclerotic patients with platelet hyperaggregation, and for clinical pharmacology studies with platelet antiaggregant drugs.
Subject(s)
Phenylbutyrates/pharmacology , Platelet Aggregation/drug effects , Administration, Oral , Adult , Drug Evaluation , Female , Humans , Injections, Intravenous , Isoindoles , Male , Middle Aged , Phenylbutyrates/administration & dosage , Platelet Function TestsABSTRACT
In this study platelet aggregation was measured by the screen filtration pressure method in 2 groups of hypertensives separated according to age. They were perfectly matched for levels of various "risk factors", with normotensive "controls". No significant difference in platelet aggregate filtration pressure (PAFP) was found between hypertensives and normotensives. Contrary to normotensive subjects, there was no significant increase in the PAFP values with age in the hypertensives. This might be due to the significantly higher blood urea values in the hypertensives as compared to the normotensives. An inverse relationship between blood urea concentration and PAFP values was in fact confirmed by in vivo and in vitro studies.
