The Movember Prostate Cancer Landscape Analysis: an assessment of unmet research needs.

Prostate cancer is a heterogeneous cancer with widely varying levels of morbidity and mortality. Approaches to prostate cancer screening, diagnosis, surveillance, treatment and management differ around the world. To identify the highest priority research needs across the prostate cancer biomedical research domain, Movember conducted a landscape analysis with the aim of maximizing the effect of future research investment through global collaborative efforts and partnerships. A global Landscape Analysis Committee (LAC) was established to act as an independent group of experts across urology, medical oncology, radiation oncology, radiology, pathology, translational research, health economics and patient advocacy. Men with prostate cancer and thought leaders from a variety of disciplines provided a range of key insights through a range of interviews. Insights were prioritized against predetermined criteria to understand the areas of greatest unmet need. From these efforts, 17 research needs in prostate cancer were agreed on and prioritized, and 3 received the maximum prioritization score by the LAC: first, to establish more sensitive and specific tests to improve disease screening and diagnosis; second, to develop indicators to better stratify low-risk prostate cancer for determining which men should go on active surveillance; and third, to integrate companion diagnostics into randomized clinical trials to enable prediction of treatment response. On the basis of the findings from the landscape analysis, Movember will now have an increased focus on addressing the specific research needs that have been identified, with particular investment in research efforts that reduce disease progression and lead to improved therapies for advanced prostate cancer.

The Changing Role of ENGOs in Water Governance: Institutional Entrepreneurs?

The changing role of the state in the last quarter century has been an important contemporary concern for policy makers, scholars, and the public. Equally, there is increasing recognition among governance scholars that nongovernment actors are exerting new kinds of influence over governance systems and contributing in novel ways to governance processes. The role of environmental nongovernmental organizations (ENGOs) is particularly pertinent given the continued involvement of ENGOs within collaborative, adaptive, and co-management governance, across several contexts and regions. This paper uses an analytical framework derived from recent studies on institutional entrepreneurs, to examine the skills ENGOs are applying in order to orchestrate change. An empirical case of governance for water in Canada's Lake Simcoe region provides the foundation for the research. Drawing on a mixed methods approach, the research finds that ENGOs in Lake Simcoe have taken on a role as an institutional entrepreneur, and thereby have altered the relationship between governance actors in this setting. A key outcome of their actions is a more dominant, engaged, and influential role for ENGOs in a critical, regional governance system.