Motor nucleus activity fails to predict extraocular muscle forces in ocular convergence.

For a given eye position, firing rates of abducens neurons (ABNs) generally (Mays et al. 1984), and lateral rectus (LR) motoneurons (MNs) in particular (Gamlin et al. 1989a), are higher in converged gaze than when convergence is relaxed, whereas LR and medial rectus (MR) muscle forces are slightly lower (Miller et al. 2002). Here, we confirm this finding for ABNs, report a similarly paradoxical finding for neurons in the MR subdivision of the oculomotor nucleus (MRNs), and, for the first time, simultaneously confirm the opposing sides of these paradoxes by recording physiological LR and MR forces. Four trained rhesus monkeys with binocular eye coils and custom muscle force transducers on the horizontal recti of one eye fixated near and far targets, making conjugate saccades and symmetric and asymmetric vergence movements of 16-27°. Consistent with earlier findings, we found in 44 ABNs that the slope of the rate-position relationship for symmetric vergence (k(V)) was lower than that for conjugate movement (k(C)) at distance, i.e., mean k(V)/k(C) = 0.50, which implies stronger LR innervation in convergence. We also found in 39 MRNs that mean k(V)/k(C) = 1.53, implying stronger MR innervation in convergence as well. Despite there being stronger innervation in convergence at a given eye position, we found both LR and MR muscle forces to be slightly lower in convergence, -0.40 and -0.20 g, respectively. We conclude that the relationship of ensemble MN activity to total oculorotary muscle force is different in converged gaze than when convergence is relaxed. We conjecture that LRMNs with k(V) < k(C) and MRMNs with k(V) > k(C) innervate muscle fibers that are weak, have mechanical coupling that attenuates their effective oculorotary force, or serve some nonoculorotary, regulatory function.

Vergence target selection in rhesus monkeys: behavior and modeling.

Previous studies have shown that a LATER (Linear Approach to Threshold with Ergodic Rate) race model can be used to explain saccadic target selection and latencies. The goal of the present study was to determine whether a comparable model could be applied to the underlying decision-making processes involved in target selection for transient vergence eye movements in rhesus monkeys. Luminance contrast of near and far Gabor pair stimuli were manipulated in a forced-choice paradigm to investigate their influence on vergence target selection. The distributions of responses and their latencies were evaluated by cumulative recinormal and reciprobit plots. With all targets set to 20% luminance contrast, animals showed a bias for the divergent target. Increasing luminance contrast of the near Gabor pair, while holding the far Gabor at the base contrast, resulted in increasing selection of the convergent target. This change in bias from divergent to convergent target selection correlated with decreases in convergent latency and increases in divergent latency. Monte Carlo simulations were used to estimate the internal rates of the divergent and convergent decision-making processes which, given a fixed threshold, would result in the observed distributions of vergence responses and their latencies. Statistical tests show that the LATER race model can predict observed values, and strongly suggests that competition between internal convergent and divergent target selection processes determines relative frequencies and latencies of these movements.