[Immune disorders and sensitization to microbial antigens in seronegative spondylitis]. / Immunnye narusheniia i sensibilizatsiia k mikrobnym antigenam pri seronegativnykh spondyloartritakh.

A study was made of immunity in seronegative spondylarthritis. In ankylosing spondylarthritis, reactive arthritides and psoriatic arthritis, the decrease of T cells, T helpers and T suppressors was identified. Patients with ankylosing spondylarthritis and reactive arthritides manifested an increase of the B-lymphocyte count. Patients with ankylosing spondylarthritis were demonstrated to be sensitive to Klebsiella (52%), those with reactive arthritides to intestinal yersinia (44%). The phenotype of antigen-binding cells was examined. Of these, 39% appeared to be T lymphocytes, 29% B lymphocytes. The presence of Fc receptors in an appreciable portion of those cells suggests their functional maturity. The inhibition test demonstrated the participation of HLA-B27 in reception of Klebsiella antigens in ankylosing spondylarthritis.

[Determination of lymphocyte receptors to Klebsiella in ankylosing spondylitis]. / Opredelenie limfotsitarnykh retseptorov k klebsielle pri ankiloziruiushchem spondiloartrite.

The authors give the results of determining receptors to Klebsiella antigens on the surface of the peripheral blood lymphocytes in ankylosing spondyloarthritis (AS). They examined 21 patients with AS, 20 patients with rheumatoid arthritis (RA) and 20 healthy individuals. Determination of the receptors was done in the reaction of indirect rosette formation. An ultrasonic disintegrate of Klebsiella culture isolated from a patient with AS was used as an antigen. Favourable results were obtained in 10 patients with AS and in none of the cases in the group of patients with RA and in healthy individuals. A higher specificity of the reaction of antigen binding lymphocytes was shown.