ABSTRACT
We studied clinical status, content of products of LPO, and oxidative modification of proteins (OMP) in the lesion focus of the intestine in experimental colitis under conditions of rectal administration of ozone. Experimental colitis was simulated by two-stage administration of oxazolone; rectal insufflation of ozone in the ozone-oxygen mixture was performed daily. The disease activity index (DAI), the content of calprotectin in the feces, and LPO and OMP products in the intestinal homogenate were assessed. On days 2, 4, and 6 of the pathological process, DAI, concentration of calprotectin in feces, content of primary, secondary, and end-products of LPO in the heptane and isopropanol phases, and content of primary and secondary OMP products progressively increases. Under conditions of ozone application, DAI, concentration of calprotectin in feces, the levels of heptane- and isopropanol-soluble primary, secondary, and end-products of LPO, and the level of primary and secondary products of OMP decreased on days 4 and 6; the level of isopropanol-soluble primary, secondary, end-products of LPO increased on day 2 of experimental colitis. The severity of clinical manifestations weakens as the content of LPO and OMP products in the colon decreases on days 4 and 6 of observation.
Subject(s)
Colitis , Ozone , 2-Propanol , Colitis/metabolism , Free Radicals/metabolism , Heptanes , Humans , Leukocyte L1 Antigen Complex , Lipids , Ozone/pharmacology , Proteins , Rectum/pathologyABSTRACT
Evaluation of blood gases and acid-base balance covered patients with carbon monoxide acute poisoning, in accordance with inhalation trauma presence. Evidence is that thermochemical injury of respiratory tract induced severe acid-base dysbalance remaining decompensated for a long time despite the treatment.
Subject(s)
Carbon Monoxide Poisoning/blood , Carbon Monoxide/blood , Acid-Base Equilibrium , Acute Disease , Adult , Blood Gas Analysis , Carbon Monoxide Poisoning/diagnosis , Female , Follow-Up Studies , Humans , Male , Middle AgedABSTRACT
The levels of neurospecific peptides in the systemic circulation and the rate of biological aging of veterans of war in Afghanistan were studied. A significant increase in the level of matrix metalloproteinase-9 reflecting the increased permeability of the blood-brain barrier in the initial manifestations of insufficient blood supply to the brain was found. After a course of general aerocryotherapy the optimization of biological and cardiopulmonary age were marked, which indicates a slowing of the biological aging.
Subject(s)
Aging, Premature/therapy , Blood-Brain Barrier , Brain Ischemia , Capillary Permeability , Cryotherapy/methods , Nerve Tissue Proteins/metabolism , Adult , Afghan Campaign 2001- , Blood-Brain Barrier/metabolism , Blood-Brain Barrier/physiopathology , Brain Ischemia/diagnosis , Brain Ischemia/metabolism , Brain Ischemia/physiopathology , Humans , Male , Matrix Metalloproteinase 9/metabolism , Treatment Outcome , Veterans , Veterans HealthABSTRACT
The pleiotropic effects of simvastatin in a daily doze of 20 mg in persons of senile age with chronic heart failure were studied in the submitted work. The practical opportunity to reduce the risk of acute vascular events, improvement of vascular endothelium function and relative safety of application of the preparation in the specified dosage at persons of senile age is shown.
Subject(s)
Endothelium, Vascular/drug effects , Heart Failure/drug therapy , Hypolipidemic Agents/therapeutic use , Lipids/blood , Simvastatin/therapeutic use , Vasodilation/drug effects , Aged, 80 and over , Chronic Disease , Dose-Response Relationship, Drug , Drug Therapy, Combination , Endothelium, Vascular/diagnostic imaging , Female , Heart Failure/blood , Heart Failure/diagnostic imaging , Heart Failure/physiopathology , Humans , Hypolipidemic Agents/administration & dosage , Male , Simvastatin/administration & dosage , Treatment Outcome , UltrasonographyABSTRACT
The study of cardiac rhythm variability (CRV) in bronchial asthma (BA) and its diagnostic significance included 265 patients aged 41.9 +/- 1.36 yr. They were examined using the rhythmocardiographic technique based on the high-resolution diagnostic system KAP-RK-01 "Mikor" (Chelyabinsk) allowing for the evaluation of sinus rhythm wave structure under conditions of targeted stimulation. Statistical and spectral analysis of CRV showed that BA is associated with autonomous dysregulation of pacemaker activity of the sinoatrial node (SAN) in the form of suppressed peripheral vegetative influence on chronotropic function and functional incompetence of SAN pacemaker cells. Non-specific CRV peculiarities of SAN dysregulation inherent in BA were demonstrated, such as decreased general variability due to reduction of the fast sympato-parasympathetic influence and enhancement of humoral and metabolic effects, impaired response to oppositely directed stimuli in the tests with lengthening the time of achievement of maximum reaction and recovery. BA patients showed very low-frequency CRV waves with a period of 35.332 +/- 8,773 s and a spectral power "peak" at 0.021 +/- 0.005 Hz. Their association with bronchial obstruction was confirmed by comparative analysis of CRV before and after intake of a bronchodilator and by correlation of CRV with the results of spirometry and peak flowmetry. The study suggests the possibility to use high-resolution rhythmocardiography in practical work of pulmonologists.
Subject(s)
Asthma/physiopathology , Autonomic Nervous System/physiopathology , Circadian Rhythm/physiology , Electrocardiography/methods , Heart Rate/physiology , Adult , Chronic Disease , Follow-Up Studies , Humans , MaleABSTRACT
Early signs of dysregulation of the cardiovascular system were revealed in 265 patients by studying peripheral vegetative regulation of pacemaker activity of the sinus node by rhythmocardiography with the use of a high-resolution KAP-RK-01 Mikor system (Chelyabinsk). Cardiac rhythm variability suggested impaired peripheral vegetative regulation of sinus node chronotropic function and functional insufficiency of pacemaker cells. Early symptoms of chronic pulmonary heart in patients with persistent asthma were associated with autonomous cardioneuropathy that correlated with structural changes in the heart. Peripheral vegetative dysregulation and functional insufficiency of pacemaker make up a pathogenetic component of cardiac disorder in patients with bronchial asthma. It is concluded that autonomous cardioneuropathy with marked suppression of sympathetic and parasympathetic regulation in the sinus node is an early manifestation of pulmonary heart development.
Subject(s)
Circadian Rhythm/physiology , Heart Rate/physiology , Pulmonary Heart Disease/physiopathology , Sinoatrial Node/physiopathology , Adult , Autonomic Nervous System/physiopathology , Chronic Disease , Humans , MaleABSTRACT
Harmful production factors are known to contribute to elevated morbidity in the population. Early detection of predictors of heart diseases is necessary in subjects exposed to occupational risk factors. Rhythmocardiography permits to diagnose autonomous cardioneuropathy in patients with vibration disease; this condition is regarded as a pathogenetic basis for the early clinical manifestation of coronary heart disease.
Subject(s)
Cardiomyopathies/physiopathology , Occupational Diseases/physiopathology , Occupational Exposure/adverse effects , Sick Sinus Syndrome/physiopathology , Vibration/adverse effects , Adult , Cardiomyopathies/complications , Electrocardiography , Female , Humans , Male , Occupational Diseases/complications , Sick Sinus Syndrome/etiologyABSTRACT
Progression from local vibration to cardiovascular pathology in patients with vibration disease is associated with remodeling cardiac and vascular tissues under effect of oxidative stress. Myocardium and nodular tissue are most vulnerable during development of occupational cardiopathy. Alteration of the heart rhythm wave structure is a predictor of remodeling.
Subject(s)
Cardiomyopathies/blood , Free Radical Scavengers/blood , Hand-Arm Vibration Syndrome/complications , Oxidative Stress/physiology , Adult , Cardiomyopathies/complications , Cardiomyopathies/diagnosis , Electrocardiography , Follow-Up Studies , Hand-Arm Vibration Syndrome/blood , Humans , Male , Middle Aged , Risk Factors , Superoxide Dismutase/bloodABSTRACT
Major death cause among occupational diseases patients is cardiovascular disorder. Early diagnosis is required to predict heart disorders in occupational risk group. Rhythmocardiography helped to define autonomous cardioneuropathy on background of vibration disease, pneumoconiosis, chronic occupational fluorine-manganese intoxication--this is a pathogenetic basis for early clinical manifestation of CHD.
Subject(s)
Cardiomyopathies/diagnosis , Cardiomyopathies/epidemiology , Echocardiography/methods , Electrocardiography , Heart Rate/physiology , Occupational Diseases/diagnosis , Occupational Diseases/epidemiology , Vibration/adverse effects , Adult , Hazardous Substances/adverse effects , Humans , Male , Occupational Diseases/chemically induced , Pneumoconiosis/epidemiology , Severity of Illness IndexABSTRACT
Cardiovascular diseases appear to be the most frequent complication and death cause in patients with various forms of occupational diseases. Autonomous nervous system could play significant role in genesis of those complications.
