Cold agglutinin disease in childhood: a case series with review of literature.

Cold agglutinins are autoantibodies that target RBC antigens at temperatures below average core body temperature. They produce RBC agglutination and cold agglutinin disease (CAD), a rare form of autoimmune haemolytic anaemia. Due to it's under recognition, there is a delay between the start of symptoms and the diagnosis. With an emphasis on the laboratory approach, we provide the clinical and analytical findings from five cases of childhood CAD.