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Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-18662872
ABSTRACT
A focused SAR exploration of the lead 4-aminoquinazoline TRPV1 antagonist 2 led to the discovery of compound 18. In rats, compound 18 is readily absorbed following oral dosing and demonstrates excellent in vivo potency and efficacy in an acute inflammatory pain model.