ABSTRACT
Introducción: El dengue se ha convertido en una de las enfermedades de mayor impacto epidemiológico, social y económico para la salud pública a nivel mundial. Objetivo: Determinar la seroprevalencia de dengue en cinco municipios del Valle del Cauca con transmisión hiperendémica y mesoendémica de la enfermedad. Métodos: Estudio de prevalencia mediante muestreo probabilístico por conglomerados multietápico. Se evaluaron 822 personas. Resultados: La seroprevalencia de dengue fue del 91,36 por ciento obtenida a partir de la aplicación de la prueba de ensayo por inmunoabsorción ligado a enzimas para dengue indirecta IgG. Al aplicar la prueba de captura para IgM para dengue, la seroprevalencia fue de un 21,41 por ciento. La seropositividad conjunta de anticuerpos IgM e IgG fue del 20,3 por ciento. Conclusiones: La alta seroprevalencia de dengue en el Valle del Cauca muestra el impacto de esta enfermedad en la historia de vida de sus residentes. Su reemergencia impacta negativamente en los que tienen como antecedentes haber padecido la enfermedad provocando un desarrollo de su variante más grave, lo que se puede evitar con la administración de una vacuna tetravalente contra el dengue(AU)
Introduction: Dengue has become one of the largest epidemiological, social, and economic impacts for global public health. Objective: To determine the seroprevalence of dengue in five municipalities of Valle del Cauca with hyperendemic and mesoendemic transmission of the disease. Methods: Prevalence study through multistage probability sampling by clusters. 822 people were assessed. Results: Seroprevalence of dengue was of 91.36 percent, it was obtained from the implementation of the enzyme-linked immunosorbent´s trial test for indirect dengue IgG. When applying the capture test IgM for dengue, seroprevalence was of 21.41 percent. The joint seropositivity of IgM and IgG antibodies was 20.3 percent. Conclusions: The high seroprevalence of dengue in Valle del Cauca shows the impact of this disease in the life history of the residents. Dengue re-emergence impacts negatively on those who have a background of having suffered from the disease which caused a development of its most severe variant that can be avoided with the administration of a quadrivalent vaccine against dengue(AU)
Subject(s)
Humans , Male , Female , Immunoglobulins , Seroepidemiologic Studies , Dengue/epidemiology , ColombiaABSTRACT
BACKGROUND: The determinants of parasite persistence or elimination after treatment and clinical resolution of cutaneous leishmaniasis (CL) are unknown. We investigated clinical and parasitological parameters associated with the presence and viability of Leishmania after treatment and resolution of CL caused by L. Viannia. METHODS: Seventy patients who were treated with meglumine antimoniate (n = 38) or miltefosine (n = 32) and cured, were included in this study. Leishmania persistence and viability were determined by detection of kDNA and 7SLRNA transcripts, respectively, before, at the end of treatment (EoT), and 13 weeks after initiation of treatment in lesions and swabs of nasal and tonsillar mucosa. RESULTS: Sixty percent of patients (42/70) had evidence of Leishmania persistence at EoT and 30% (9/30) 13 weeks after treatment initiation. A previous episode of CL was found to be a protective factor for detectable Leishmania persistence (OR: 0.16, 95%CI: 0.03-0.92). kDNA genotyping could not discern differences between parasite populations that persisted and those isolated at diagnosis. CONCLUSIONS: Leishmania persist in skin and mucosal tissues in a high proportion of patients who achieved therapeutic cure of CL. This finding prompts assessment of the contribution of persistent infection in transmission and endemicity of CL, and in disease reactivation and protective immunity.
