ABSTRACT
Lymphadenopathy is an age old affliction of mankind. It is one of the very common presentations in clinical practice. The present study was carried out to evaluate the merits and demerits of fine needle aspiration cytology (FNAC) as a diagnostic procedure in childhood lymphadenopathy in comparison to open surgical biopsy. Altogether 70 children with lymphadenopathy in the age group of up to 12 years were selected for FNAC. Only 38 could be motivated for open surgical biopsy. Out of 38 cases, FNAC was consistent with histopathology in 33 cases, thus giving a diagnostic accuracy or percentage of agreement-86.8%. The diagnostic accuracy of FNAC, sensitivity, specificity, positive predictive values of FNAC in the present study were fairly high ranging from 80%-100%. FNAC gave false positive diagnosis in 13.2% cases and false negative result in 13.2% cases.
Subject(s)
Biopsy, Fine-Needle , Cytodiagnosis/methods , Lymph Nodes/pathology , Lymphatic Diseases/diagnosis , Child , False Negative Reactions , False Positive Reactions , Humans , Lymphatic Diseases/pathology , NeckABSTRACT
Four groups of subjects: normal healthy normotensive nonpregnant women (Group A), normal normotensive pregnant women (Group B), women with preeclamptic toxaemia (Group C) and eclamptic women (Group D): with fifty subjects in each group, were investigated for serum lipid profile in the third trimester of pregnancy. There was significant increase in serum triglyceride and VLDL cholesterol leve as well as decrease in LDL cholesterol in normal pregnancy, while total cholesterol and HDL cholesterol levels did not show any statistically significant alteration. The preeclampsia (Group C) was associated with a significant rise in triglyceride and VLDL cholesterol and fall in HDL cholesterol concentration, while eclamptic women showed significant fall in HDL cholesterol and rise in LDL cholesterol as compared to normal pregnant women. However, interestingly, elevation of the ratios of total cholesterol: HDL cholesterol and triglyceride: HDL cholesterol as well as diminuition of the ratio of HDL cholesterol: VLDL cholesterol showed statistical significance in pregnancy induced hypertension in both Groups C and D, while eclamptic women showed significant elevation of LDL cholesterol: HDL cholesterol ratio in addition.
