Luminogenic and Bactericidal Studies of an Acrylonitrile-Based AIEgen.

We have synthesized an aggregation-induced emissive molecule that exhibits promising photophysical characteristics. The aggregating aptitude is demonstrated by binary solvent mixture and it is emissive in both solution and solid state. The luminogenic characteristics are employed in creating fluorescent inks as well as for the detection of nitro antibiotics in biofluids and in solid support. Moreover, the acrylonitrile-based compound is bactericidal tested on E. coli and B. subtilis.

Amphiphilic polyphenol incorporated hydrogel derived from mucoadhesive of Dillenia indica: Potential antioxidant and adsorbent.

In this work, the mucoadhesive substances from the fruits and seeds of Dillenia indica (DI), a plant present abundantly in India, have been extracted and utilised to prepare a hydrogel. A synthetically prepared amphiphilic polyphenol (L) has been incorporated within the hydrogel network to enhance the hydrogelation property. Moreover, the DI-L hydrogel's total phenolic content and radical scavenging prospects have been investigated. The DI-L hydrogel has shown good, sensitive, and efficient adsorptive removal of Fe(III) from the aqueous medium with an adsorption capacity of 6.157 mg/g for an initial concentration of 10 mg/L of Fe(III) solution. As a result, these findings elucidate the most innovative application of transforming fruit mucoadhesive into sustainable environmental solutions.

Inhibition of staphylococcal nuclease by benzimidazole-based Ligand: Implications in DNA-Mediated entrapment and uptake of MRSA by Macrophage-like cells.

The staphylococcal nuclease also referred as micrococcal nuclease (MNase) is a key drug target as the enzyme degrades the neutrophil extracellular trap (NET) and empowers the pathogen to subvert the host innate immune system. To this end, the current study presents a critical evaluation of MNase inhibition rendered by benzimidazole-based ligands (C1 and C2) and probes its therapeutic implications. A nuclease assay indicated that MNase inhibition rendered by C1 and C2 was âˆ¼ 55 % and âˆ¼ 72 %, respectively, at the highest tested concentration of 10 µM. Studies on enzyme kinetics revealed that C2 rendered non-competitive inhibition and significantly reduced MNase turnover number (Kcat) and catalytic efficiency (Kcat/Km) with an IC50 value of âˆ¼ 1122 nM. In CD spectroscopy, a notable perturbation in the ß-sheet content of MNase was observed in presence of C2. Fluorescence-microscope analysis indicated that MNase inhibition by C2 could restore entrapment of methicillin-resistant Staphylococcus aureus (MRSA) in calf-thymus DNA (CT-DNA). Flow cytometry and confocal microscope analysis revealed that uptake of DNA-entrapped MRSA by activated THP-1 cells was reinstated by MNase inhibition rendered by C2. Inhibition of nuclease by the non-toxic ligand C2 holds therapeutic prospect as it has the potential to bolster the DNA-mediated entrapment machinery and mitigate MRSA infections.

Surfactant-induced disaggregation of a quinoxaline AIEgen scaffold: aggregation aptitude in the solid and solution states.

We have designed five propellor-shaped molecules based on the quinoxaline scaffold with a functional group variation. They exhibit aggregation-induced emission, and the responses of these congeners regarding good solvents and poor solvents are investigated both spectroscopically and microscopically. Solid- as well as solution-state parallel analysis of the aggregation facet is laid out. Notably, L2 interacts specifically with a cationic surfactant, unlike other congeners where the mechanism proceeds via disaggregation. Real sample analysis was carried out on freshwater samples as well as waste effluent samples from domestic households and industries, thus projecting the analytical and environmental significance.

Carbazole-Derived Amphiphile-Based AIEgen: Detection of Nitro-Antibiotics and Water-Repelling Surfaces.

We have designed three amphiphilic substituted urea compounds with varying chain lengths. These hydrophobic amphiphiles displayed aggregation-induced emission on solvent switching. The aggregates were further detailed by microscopy. The hydrophobicity of these AIEgens has been used to create water-repelling fluorescent surfaces. The AIEgen via the photoinduced electron transfer-mediated mechanism has been applied in the detection of nitroantibiotics. The analytical utility of the AIEgen is being demonstrated concerning the detection of nitroantibiotics in biofluids.

Exploring the Aggregation and Light-Harvesting Aptitude of Naphthalimide-Based Amphiphile and Non-amphiphile AIEgen.

Herein, we report a comparative study of two naphthalimide-tethered amphiphile and non-amphiphile with their aggregation-induced emission properties. A synthetic modulation of a hydrophobic tail on the framework repressed the ACQ-phoric fluorophore to an AIEgen. L1 and L2 remain in the dispersed form in DMF and exhibits aggregation and intense emission signal in aqueous media. Microscopy detailing of the aggregating process has been analyzed. Not only the AIEgens are emissive in water but also they are emissive in the solid state. The natural light-harvesting process is mimicked by the aggregated state, establishing an energy transfer process between L1 and commercial dye. Disaggregation of the AIEgen has also been utilized in the detection of nitroaromatics. Analytical utility of the AIE-gen is being demonstrated concerning the detection of explosives in aqueous media.