Subject(s)
AIDS-Related Opportunistic Infections/drug therapy , Antiviral Agents/therapeutic use , Epidermodysplasia Verruciformis/drug therapy , Hepatitis C/drug therapy , Interferon-alpha/therapeutic use , Ribavirin/therapeutic use , AIDS-Related Opportunistic Infections/virology , Coinfection/drug therapy , Coinfection/virology , Epidermodysplasia Verruciformis/virology , Humans , Male , Middle Aged , Papillomaviridae/isolation & purificationSubject(s)
Anti-Inflammatory Agents/adverse effects , Antibodies, Monoclonal/adverse effects , Arthritis, Psoriatic/drug therapy , Mycobacterium Infections, Nontuberculous/etiology , Humans , Infliximab , Male , Middle Aged , Mycobacterium Infections, Nontuberculous/chemically induced , Mycobacterium Infections, Nontuberculous/drug therapy , Tumor Necrosis Factor-alpha/antagonists & inhibitorsSubject(s)
Carcinoma, Papillary/secondary , Lymphatic Metastasis/diagnosis , Parotid Neoplasms/pathology , Salivary Ducts/pathology , Aged , Biomarkers, Tumor/analysis , Carcinoma, Acinar Cell/diagnosis , Carcinoma, Mucoepidermoid/diagnosis , Carcinoma, Papillary/chemistry , Carcinoma, Papillary/diagnosis , Carcinoma, Papillary/pathology , Carcinoma, Papillary/surgery , Diagnosis, Differential , ErbB Receptors/analysis , Humans , Keratin-7/analysis , Lymphatic Metastasis/pathology , Male , Mucin-1/analysis , Neoplasms, Unknown Primary/diagnosis , Parotid Neoplasms/chemistry , Parotid Neoplasms/diagnosis , Parotid Neoplasms/surgery , Receptor, ErbB-2/analysis , Receptors, Androgen/analysisSubject(s)
Maxillary Neoplasms/diagnosis , Neuroectodermal Tumor, Melanotic/diagnosis , Biomarkers, Tumor/analysis , Female , Humans , Infant , Maxillary Neoplasms/chemistry , Maxillary Neoplasms/pathology , Maxillary Neoplasms/surgery , Neoplasm Invasiveness , Neuroectodermal Tumor, Melanotic/chemistry , Neuroectodermal Tumor, Melanotic/pathology , Neuroectodermal Tumor, Melanotic/surgery , Orbit/pathology , Orbit/surgeryABSTRACT
BACKGROUND: To evaluate the feasibility of aortic balloon catheter occlusion in intra-abdominal hemorrhage. METHODS: Effects of transfemoral diaphragmatic aortic balloon occlusion (ABO) have been evaluated in 25 pigs. The animals were submitted to incontrollable hemorrhage by a splenic trauma. Group 1 (n = 9) received fluid resuscitation with normal saline (NS) without aortic occlusion; group 2 (n = 8) underwent 60 minutes ABO and NS. Groups 3 (n = 4) and 4 (n = 4) underwent ABO during 40 minutes and 60 minutes, respectively, NS, and splenectomy. RESULTS: Aortic balloon location was adequate in all animals. ABO increased the portion of 2-hour survivors significantly (7/16 vs. 0/9; p = 0.03). ABO increased mean arterial blood pressures (p < 0.05). There was a significant decrease of bleeding and volume of fluid resuscitation (p < 0.05) in ABO groups. Blood potassium and lactate levels at death were significantly higher in groups 2 and 4 compared with those of the control group: 29 ± 0.54 and 6.08 mmol/L ± 0.44 mmol/L versus 4.16 mmol/L ± 0.35 mmol/L (p < 0.02), and 11.39 mmol/L ± 0.37 mmol/L and 9.59 mmol/L ± 1.19 mmol/L versus 6.43 mmol/L ± 0.57 mmol/L (p < 0.001), respectively. There were no significant differences between group 3 and the control group: 4.83 mmol/L ± 0.32 mmol/L versus 6.43 mmol/L ± 0.57 mmol/L and 5.2 mmol/L ± 0.13 mmol/L versus 4.16 mmol/L ± 0.35 mmol/L, respectively. At necropsy, there were no significant differences in terms of visceral (bowel and kidney) ischemia between the different experimental groups. CONCLUSION: A 40-minute ABO followed by surgical damage control improved survival in this animal model of uncontrolled hemorrhagic shock caused by abdominal trauma. ABO could be considered for the management of severe abdominal trauma.
Subject(s)
Abdominal Injuries/therapy , Aorta , Balloon Occlusion , Shock, Hemorrhagic/therapy , Abdominal Injuries/etiology , Animals , Disease Models, Animal , Fluid Therapy , Shock, Hemorrhagic/etiology , Splenectomy , Swine , Time FactorsABSTRACT
A 35-year-old man with a stage I non-seminomatous germ-cell tumor of the right testis was treated with a simple orchidectomy. Sixty-seven months later, the patient who was on clinical follow-up, has presented five bilateral lung nodules on computed-tomography scan. Additional staging showed no other abnormalities. Lung biopsy of two nodules was performed during a videothoracoscopy and the histologic examination revealed a sarcoidosis-like necrotizing granulomatosis. The coexistence of non-caseating granulomas and testis carcinoma showed an increase during the last two decades. The immunopathogenesis of sarcoid formation in malignant tumours is still unknown. During follow-up of patients with testicular carcinomas, the presence of lung nodules requires a histologic examination and sarcoidosis should be considered as differential diagnosis.
