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Eur J Pediatr ; 164(3): 158-61, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15578220

ABSTRACT

UNLABELLED: Methanol poisoning is not frequently observed in children; however, without treatment, serious intoxication can be complicated by visual impairment, coma, metabolic acidosis, respiratory and circulatory insufficiency and death. Treatment in a paediatric intensive care is therefore compulsory. Methanol is metabolised in the liver by alcohol dehydrogenase to the toxic metabolites formaldehyde and formic acid. Classically, ethanol is given as a competitive inhibitor in order to avoid the formation of these compounds. We report on the use of fomepizole (4-methylpyrazole),a new and potent inhibitor of alcohol dehydrogenase, in a 3-year-old boy after the intake of a toxic amount of methanol. The course was uneventful and the use of fomepizole was not accompanied by any side-effects. An overview is given of all cases of paediatric poisoning in which fomepizole was used. CONCLUSION: Fomepizole seems to be a safe and valid alternative to ethanol in cases of paediatric methanol poisoning.


Subject(s)
Antidotes/therapeutic use , Methanol/poisoning , Pyrazoles/therapeutic use , Solvents/poisoning , Child, Preschool , Drug Therapy, Combination , Fomepizole , Humans , Leucovorin/therapeutic use , Male , Poisoning/drug therapy
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