ABSTRACT
BACKGROUND: Although recognition of colorectal malignant polyps is increasing, treatment plans lack the evidence of randomised trials. AIM: To retrospectively evaluate presentation, management and outcomes of screen-detected colorectal malignant polyps, with special focus on the role of histological factors in therapeutic decision-making. METHODS: We retrospectively analysed data regarding malignant polyps detected during faecal immuno-chemical test-based screening programmes in five centres in North-Eastern Italy between April 2008 and April 2013. RESULTS: 306 malignant polyps in 306 patients were included; 72 patients underwent surgery directly (23.6%). Of 234 patients treated endoscopically, 133 subsequently underwent radicalisation surgery (56.8%) and in 17 there was evidence of residual disease (12.8%). Involved, unsafe (<1mm) or invaluable resection margins and sessile morphology represented the most frequent determinants of subsequent surgery. The mean number of nodes harvested during radicalisation surgery was 7.1±6.4 (range 0-29). Histological diagnosis was re-evaluated according to new guidelines in 125 cases (41%); in 18 this led to modification of the risk class (14.4%). CONCLUSIONS: Although the rate of surgical treatment following endoscopic resection is similar to other studies, residual disease at surgery was lower than most international series. Adhering to the new histological reporting system and respecting guidelines on node harvesting may favourably influence prognosis.
Subject(s)
Carcinoma/pathology , Carcinoma/surgery , Colonic Polyps/pathology , Colonic Polyps/surgery , Colorectal Neoplasms/pathology , Colorectal Neoplasms/surgery , Lymph Node Excision , Occult Blood , Aged , Carcinoma/secondary , Colonoscopy , Decision Making , Early Detection of Cancer , Female , Guideline Adherence , Humans , Italy , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm, Residual , Practice Guidelines as Topic , Reoperation , Retrospective Studies , Risk Assessment , Tumor BurdenABSTRACT
A 68-year-old male presented with rapidly progressive paraplegia. MR images of the thoracic spine were interpreted as being consistent with an abscess within an epidural lipomatosis compressing the spinal cord. Laminectomy was performed, and a large amount of pus was drained from the epidural lipomatosis, from which Staphylococcus aureus was isolated. This is the first reported case of an abscess involving an epidural lipomatosis.
