ABSTRACT
BACKGROUND: Volatile anaesthetics have an influence on small bowel peristalsis during laparoscopic surgery. A recent study concluded that desflurane increased intestinal motility compared to sevoflurane. Hence, a desflurane-based anaesthesia protocol may reduce surgical exposure during intestinal suturing or stapling due to small bowel hyperperistalsis. The effect of propofol on intestinal motility is not well studied. We tested the hypothesis that a propofol-remifentanil anaesthesia increases intestinal contractions in comparison with a sevoflurane-remifentanil anaesthesia. METHODS: Patients scheduled for laparoscopic gastric bypass surgery were randomized in this single blind randomized controlled trial to receive remifentanil combined with sevoflurane or propofol (ISRCTN 12921661). Bispectral index monitoring was used to guide depth of anaesthesia. Visual observation of peristaltic waves was performed during 1 min at the planned site of the jejunostomy. Statistical analysis was performed using Wilcoxon two-sample test. RESULTS: After obtaining written informed consent 50 patients were included. Groups were similar for demographic variables, and depth of anaesthesia during the observations. The median number of peristaltic waves was lower in the sevoflurane-remifentanil group compared to the propofol-remifentanil group (0 vs. 6, P < 0.001). CONCLUSION: Propofol-remifentanil increases intestinal motility compared with sevoflurane-remifentanil during laparoscopic gastric bypass surgery. A sevoflurane-based protocol can help to avoid disturbing peristalsis.
Subject(s)
Anesthetics/pharmacology , Gastrointestinal Motility/drug effects , Laparoscopy , Methyl Ethers/pharmacology , Propofol/pharmacology , Adult , Calcium Channels/physiology , Electroencephalography/drug effects , Female , Humans , Male , Middle Aged , Nerve Tissue Proteins/physiology , Prospective Studies , Sevoflurane , Single-Blind Method , TRPA1 Cation Channel , TRPV Cation Channels/physiology , Transient Receptor Potential Channels/physiologyABSTRACT
BACKGROUND: Hyperperistalsis of the small bowel during laparoscopic surgery may cause mucosal prolapse and reduce exposure, making laparoscopic suturing or stapling more demanding for the surgeon. Although it is commonly accepted that both opioids and volatile anaesthetics induce intestinal paralysis, intestinal hyperactivity during anaesthesia is not uncommon. This randomized trial investigated the effect of different volatile anaesthetics on intestinal motility and the impact on surgeon satisfaction. METHODS: Patients scheduled for laparoscopic gastric bypass surgery were randomized to receive sevoflurane or desflurane in a balanced anaesthetic regimen. After surgical exposure peristaltic waves were counted over 1 min in a segment of the jejunum. Following evaluation of intestinal motility, N-butylhyoscine, an antimuscarinic anticholinergic agent that relaxes bowel smooth muscle cells, could be administered if the surgeon judged the intestinal motility as disturbing. The endpoints were number of peristaltic waves and incidence of N-butylhyoscine administration, a surrogate for surgeon satisfaction. RESULTS: Twenty-two patients were randomized to each group. The groups were similar in age, sex and body mass index. There was a statistically significant difference in intestinal motility between the desflurane and sevoflurane groups: median (range) 7 (0-12) versus 1 (0-10) waves counted over 1 min respectively (P < 0·001). A higher proportion of patients in the desflurane group received N-butylhyoscine (10 of 22 versus 1 of 22 in the sevoflurane group; P = 0·004). CONCLUSION: Desflurane increased intestinal motility and decreased surgeon satisfaction compared with sevoflurane during laparoscopic gastric bypass surgery. A sevoflurane-based anaesthetic protocol can help to avoid disturbing hyperperistalsis. REGISTRATION NUMBER: B39620097060 (http://www.clinicaltrials.be).
Subject(s)
Anesthetics, Inhalation , Gastric Bypass/methods , Gastrointestinal Motility/drug effects , Isoflurane/analogs & derivatives , Laparoscopy/methods , Methyl Ethers , Adult , Body Mass Index , Desflurane , Double-Blind Method , Female , Humans , Male , Muscarinic Antagonists/pharmacology , Prospective Studies , Scopolamine/pharmacology , SevofluraneABSTRACT
Up to a little while ago there was no uniform definition for acute kidney injury (AKI). Recently, the Acute Dialysis Quality Initiative proposed the RIFLE consensus classification for AKI. This classification was adapted and modified by the Acute Kidney Injury Network into the AKI staging system. This classification defines 3 stages of severity of AKI, including less severe AKI. The incidence of AKI in ICU patients is increasing; severe AKI, treated by renal replacement therapy (RRT), has now an incidence comparable to that of acute lung injury/acute respiratory distress syndrome (ALI/ARDS), and less severe AKI has an incidence comparable to that of sepsis. The prognosis of patients with AKI treated with RRT is still dim, with mortality rates between 50% and 60%. It is important to know that AKI is not only a consequence of severe disease, but also contributes to its worse outcome. Severe AKI, and less severe AKI, as defined by the AKI classification, have an independent association with mortality.
