ABSTRACT
OBJECTIVE: To evaluate volumetric changes of uterine myomas (fibroids) during pregnancy. METHODS: This was an observational, longitudinal and prospective study of 38 consecutive Caucasian women with singleton pregnancies and a total of 42 uterine myomas, enrolled from a cohort of 1492 women who took part in our first-trimester Down syndrome screening program. Myoma volume was evaluated by ultrasound at 11-14, 20-22 and 32-34 weeks of gestation. RESULTS: Mean myoma volume increased significantly throughout pregnancy. Taking a volumetric change of > 10% between gestational periods to be an increase in size, 71.4% of uterine myomas increased in size between the first and second gestational periods, while this percentage was slightly lower (66.6%) between the second and third periods. Logistic regression analysis revealed that greater maternal age was correlated with a reduction/no change in overall myoma size and multiparity was correlated with a decrease/no change between the first and second trimesters, while a higher prepregnancy maternal body mass index (BMI) was correlated with a volumetric increase between the first and second trimesters and a decrease/no change between the second and third trimesters. CONCLUSIONS: Fibroids enlarge during pregnancy regardless of their initial size or local factors, and maternal age, prepregnancy BMI and parity are apparently correlated with these changes.
Subject(s)
Leiomyoma/diagnostic imaging , Pregnancy Complications, Neoplastic/diagnostic imaging , Tumor Burden , Uterine Neoplasms/diagnostic imaging , Adult , Down Syndrome/diagnostic imaging , Female , Humans , Leiomyoma/complications , Leiomyoma/pathology , Longitudinal Studies , Mass Screening , Pregnancy , Pregnancy Complications, Neoplastic/pathology , Pregnancy Outcome , Pregnancy Trimester, First , Prospective Studies , Regression Analysis , Ultrasonography , Uterine Neoplasms/complications , Uterine Neoplasms/pathologyABSTRACT
Heterotopic pregnancy is the simultaneus development of an intrauterine pregnancy and ectopic pregnancy. It is a potentially fatal condition and rarely occurrs in natural conception cycles. A high incidence of heterotopic pregnancy is reported in pregnancies following an assisted reproduction technique (ART) with embryo transfer in utero. We report the case of heterotopic pregnancy via ART in a 42-year-old primigravida. She presented with pelvic pain and intraabdominal fluid collection. She was treated with laparoscopic surgery. At present the intrauterine pregnancy is in normal evolution.
Subject(s)
Pregnancy, Ectopic/diagnosis , Adult , Female , Humans , Laparoscopy , Pelvic Pain/etiology , Pregnancy , Pregnancy, Ectopic/surgery , Reproductive Techniques, AssistedABSTRACT
The study included 64 postmenopausal women with adnexal masses. The selection criteria included menopausal status, an ultrasound scan indicating a benign mass and serum levels of CA-125 below the cutoff (35 U/ml). The results of the study confirm that the removal of a cystic mass in postmenopausal patients with laparoscopic surgery is a more valid and acceptable alternative to traditional surgery.
Subject(s)
Adnexal Diseases/surgery , Cysts/surgery , Gynecologic Surgical Procedures/methods , Laparoscopy/methods , Adnexal Diseases/diagnostic imaging , Adnexal Diseases/pathology , Aged , Aged, 80 and over , CA-125 Antigen/blood , Female , Humans , Middle Aged , Postmenopause , UltrasonographyABSTRACT
Ellis-van Creveld (EvC) syndrome, or chondroectodermal dysplasia, is a rare genetic disorder associated with chondrodysplasia, ectodermal dysplasia, polydactyly, and congenital cardiac malformations. The disorder is due to an autosomal-recessive mutation mapped to chromosome 4p16. It may occur with different phenotypes. The case of an ovarian endometriotic cyst in a patient suffering from EvC syndrome is reported.
