Multidisciplinary treatment approach in Treacher Collins syndrome.

Treacher Collins syndrome (TCS) is a common genetic disorder with high penetrance and phenotypic variability. First and second branchial arches are affected in TCS, resulting in craniofacial and intraoral anomalies such as: severe convex facial profile; mid-face hypoplasia; microtia; eyelid colobomas; mandibular retrognathism; cleft palate; dental hypoplasia; heterotopic teeth; maxillary transverse hypoplasia; anterior open bite; and Angle Class II molar relationship. A high incidence of caries is also a typical finding in TCS patients. Nonetheless, even simple dental restorative procedures can be challenging in this patient population due to other associated medical conditions, such as: congenital heart defects; decreased oropharyngeal airways; hearing loss; and anxiety toward treatment. These patients often require a multidisciplinary treatment approach, including: audiology; speech and language pathology; otorhinolaryngology; general dentistry; orthodontics; oral and maxillofacial surgery; and plastic and reconstructive surgeries to improve facial appearance. This paper's purpose was to present a current understanding of Treacher Collins syndrome etiology, phenotype, and current treatment approaches.

Long-term effects of orthodontic therapy on the maxillary dental arch and nasal cavity.

INTRODUCTION: Rapid maxillary expansion (RME) can enlarge the maxillary dental arch while increasing nasal cavity volume and nasal valve area, and decreasing upper airway resistance over time. However, the long-term effects of RME on arch morphology and nasal cavity geometry in patients treated with RME compared with the general population are unclear. METHODS: Three-dimensional morphometic analysis and acoustic rhinometry were used to evaluate the maxillary dental arches and nasal cavities in a post-RME-treatment group (n = 25) and a control group (n = 25). RESULTS: Palatal area and volume increased substantially after expansion and remained stable until posttreatment. Small increases in intermolar distance were not significant between the time points. Nasal airway resistance significantly decreased after RME and remained stable until posttreatment. Nasal cavity volume was stable during expansion and posttreatment. It increased significantly during expander stabilization and 9-12 months after expander removal. The minimal cross-sectional area significantly increased between the end of expansion and expander removal and remained stable until posttreatment. All measurements were comparable with those of the matched controls at posttreatment except for palatal area, which was smaller in the treatment group. CONCLUSIONS: RME is a powerful tool to normalize most of the variables investigated. Edgewise orthodontic treatment and a retention regimen that consisted of maxillary circumferential or traditional Hawley retainers met satisfactory standards to stabilize the achieved outcomes. Future studies should include morphometric, functional, and skeletal analyses so that the effects of growth and remodeling are better elucidated.