ABSTRACT
A new amphiphilic, high-molecular weight poly (N-acryloylmorpholine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liquid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H activity. Its antisense activity against an HIV-1 target has been also evaluated.
Subject(s)
Morpholines/pharmacology , Oligonucleotides, Antisense/pharmacology , Ribonuclease H/metabolism , Gene Expression Regulation/drug effects , Glucosides , Inosine/analogs & derivatives , Molecular Structure , Molecular Weight , Morpholines/chemical synthesis , Morpholines/chemistry , Nucleic Acid Denaturation , Oligonucleotides, Antisense/chemical synthesis , Oligonucleotides, Antisense/chemistry , Polyethylene Glycols/chemistry , SolubilityABSTRACT
This paper reports a case of an histological non aggressive thymoma with myasthenic symptoms as the first clinical manifestation. Three years after its complete surgical resection liver metastases appeared without evidence of intrathoracic neoplastic disease. The extrathoracic metastases are uncommon and the thymomatous myasthenia gravis is present in 25 to 50% of cases. We reviewed the literature and analyzed its clinical pathological characteristics and therapeutics approach.
