1.
Cytogenet Cell Genet
; 68(3-4): 203-6, 1995.
Article
in English
| MEDLINE
| ID: mdl-7842737
ABSTRACT
Aneuploidy detection for chromosome 21 by fluorescence in situ hybridization (FISH) to interphase nuclei using a probe specific for the alphoid DNA sequences D21Z1/D13Z1 should be avoided. An extreme heteromorphism, resulting in misdiagnosis if interphase FISH is the only test employed, may be far more frequent (4/101) than expected.