MADIA - Meteorological variables for agriculture: A dataset for the Italian area.

The MADIA gridded dataset provides the dekadal series of the main agro-meteorological variables derived from ERA5 hourly surface data, across Italy for the period 1981-2021, and their respective 1981-2010 and 1991-2020 climate normals, also including absolute minimum and maximum and the main quantiles. Temporal and spatial resolutions are 10-day and 0.25 degrees respectively and the dataset is annotated with standard metadata. The dataset was obtained by: (1) estimating the daily time series of minimum, average and maximum air temperature, minimum and maximum air relative humidity, wind speed, surface solar radiation downwards, precipitation and reference evapotranspiration according to the FAO Penman-Monteith method; (2) summarising them to 10-day series as accumulated values for precipitation and evapotranspiration and mean values for the other variables. The MADIA dataset is provided in both NetCDF and csv format. A complementary vector file is provided which reports for every cell the fractions covered of the total area of each administrative unit considered to derive statistics for Italy on the European Nomenclature of Territorial Units for Statistics levels (NUTS 2 and 3). Other potential dataset reuses are the estimation of bioclimatic indices and statistical downscaling of climate scenarios.

Long-term proactive management of psoriasis with calcipotriol and betamethasone dipropionate foam: an Italian consensus through a combined nominal group technique and Delphi approach.

BACKGROUND: Although long-term management of psoriasis is paramount, this approach is challenging in clinical practice. In the recent PSO-LONG trial, a fixed-dose combination of betamethasone dipropionate (BD) and calcipotriol (Cal) foam applied twice a week on non-consecutive days for 52 weeks (proactive treatment) reduced the risk of relapse. However, the role of Cal/BD foam in the long-term management of psoriasis needs further clarifications. The ProActive Management (PAM) program, a nationwide Italian project, aims at reaching a consensus on the role of proactive management of psoriasis. METHODS: A steering committee generated some statements through the nominal group technique (NGT). The statements were voted by an expert panel in an adapted Delphi voting process. RESULTS: Eighteen statements were proposed, and the majority of them (14/18) reached a consensus during the Delphi voting. The need to provide long-term proactive topical treatment to reduce the risk of relapse for the treatment of challenging diseases sites or in patients where phototherapy or systemic therapies are contraindicated/ineffective was widely recognized. A consensus was reached about the possibility to associate the proactive treatment with systemic and biological therapies, without the need for dose intensification, thus favoring a prolonged remission. Moreover, the proactive treatment was recognized as more effective than weekend therapy in increasing time free from relapses. Approaches to improve adherence, on the other hand, need further investigation. CONCLUSIONS: The inclusion in guidelines of a proactive strategy among the effective treatment options will be a fundamental step in the evolution of a mild-moderate psoriasis therapeutic approach.

Tasting the Italian Terroir through Craft Beer: Quality and Sensory Assessment of Cascade Hops Grown in Central Italy and Derived Monovarietal Beers.

The present study aimed to chemically and sensorially characterize hop samples, cv Cascade, grown in two different Italian regions (Latium and Tuscany) as well as their derived beers by a multi analytical approach. Significant differences in bitter acid, oil and polyphenol content were observed for hop samples according to their origin. Gas chromatography-olfactometry analysis pointed out floral notes for Tuscany samples, where hops from Latium were characterized by spicy and resinous notes, correlated to the presence of sesquiterpenes. Differences in the molecular fingerprinting were also highlighted by Fourier-Transform Infrared Spectroscopy. The differences found in the hops were reflected in the beers, which were clearly recognized as distinct by a sensory panel. Both beer samples were mainly characterized by six aroma compounds (linalool, geraniol and ß-damascenone, citronellol, 2-phenylethyl acetate, and 2-phenylethanol), three of which were potentially responsible for the geographic origin of the hops given their significantly different concentrations.

Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams.

BACKGROUND AND PURPOSE: The purpose of this study was to add, to the objective evaluation, an instrumental assessment of the skin damage induced by radiation therapy. MATERIALS AND METHODS: A group of 100 patients affected by breast cancer was recruited in the study over one year. Patients were divided into five groups of 20 patients. For each group it was prescribed a different topical treatment. The following products were used: Betaglucan, sodium hyaluronate (Neoviderm®), Vitis vinifera A. s-I-M.t-O.dij (Ixoderm®), Alga Atlantica plus Ethylbisiminomethylguaicolo and Manganese Cloruro (Radioskin1®) and Metal Esculetina plus Ginko Biloba and Aloe vera (Radioskin 2®); Natural triglycerides-fitosterols (Xderit®); Selectiose plus thermal water of Avene (Trixera+®). All hydrating creams were applied twice a day starting 15 days before and one month after treatment with radiations. Before and during treatment patients underwent weekly skin assessments and corneometry to evaluate the symptoms related to skin toxicity and state of hydration. Evaluation of acute cutaneous toxicity was defined according to the RTOG scale. RESULTS: All patients completed radiotherapy; 72% of patients presented a G1 cutaneous toxicity, 18% developed a G2 cutaneous toxicity, 10% developed a G3 toxicity, no one presented G4 toxicity. The corneometry study confirmed the protective role of effective creams used in radiation therapy of breast cancer and showed its usefulness to identify radiation-induced dermatitis in a very early stage. CONCLUSIONS: The preventive use of topic products reduces the incidence of skin side effects in patients treated with radiotherapy for breast cancer. An instrumental evaluation of skin hydration can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree. All moisturizing creams used in this study were equally valid in the treatment of skin damage induced by radiotherapy.

Quality control procedures in the Italian national forest inventory.

National forest inventories represent a fundamental source of data and knowledge for forestry and environmental policy and allow for the production of national and regional level statistics on forests. The value of these statistics confirms the need for a sampling design that adequately delivers representation by reducing sampling error, but also for a data quality process that limits the non-sampling errors. The article summarizes the quality control procedures of the three sampling phases adopted in the Italian national forest inventory, carried out between 2003 and 2006. The development of an integrated system of actions and controls which are able to limit subjective interpretations, in order to guarantee harmonized information all over the country, was a considerable effort within the overall project. Critical points to be considered were the consistent number of measures and evaluations undertaken during the three inventory phases, the high variability of observed attributes, the consistent number of surveyors involved, and costs of quality control, especially those related to fieldwork. At the end, examples on the overall quality of the classification performed on land cover and vegetation are discussed, as well as the impact of classification errors on the total forest area estimates.

Dermoscopy of microvenular hemangioma: report of a case.

We describe a 31-year-old woman with an asymptomatic solitary red plaque on the back which measured 2 x 1 cm. The patient reported that it had been growing for a few months. Upon dermoscopic examination, multiple well-demarcated red globules were seen. At the periphery a fine pigment network was present. The lesion was excised and examined histopathologically. The specimen showed proliferation of irregular branching venules with inconspicuous lumina. The tumor cells lacked cellular atypia. Microvenular hemangioma is a rare, slowly growing, benign vascular tumor. It usually presents on the trunk or the extremities of young to middle-aged adults. Microvenular hemangioma is a benign vascular tumor with distinct dermoscopic and histopathological features which enable it to be distinguished from other vascular neoplasms.