ABSTRACT
INTRODUCTION: Osteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronate and/or zoledronic acid have a delayed eruption age compared to a control group of healthy children. METHODS: An ambispective longitudinal cohort study evaluating the age of eruption of the first stage mixed dentition in a group of children with OI (n = 37) all treated with intravenous bisphosphonates compared with a group of healthy children (n = 89). Within the study group, the correlation (Pearson correlation test) between the type of medication administered (pamidronate and/or zoledronic acid) and the chronology of tooth eruption is established, as well as the relationship between the amount of cumulative dose received and tooth eruption. RESULTS: The age of eruption of the study group was significantly delayed compared to the age of eruption of the control group for molars and lateral incisors (p < 0.05). Patients who received higher cumulative doses had a delayed eruption age compared to those with lower cumulative doses (p < 0.05). There is a high positive correlation between age of delayed tooth eruption and Zoledronic acid administration. CONCLUSION: Patients with OI have a delayed eruption of the 1st stage mixed dentition compared to a control group of healthy children. This delayed eruption is directly related to the cumulative dose of bisphosphonates and the administration of zoledronic ac.
Subject(s)
Bone Density Conservation Agents , Osteogenesis Imperfecta , Child , Animals , Humans , Pamidronate/therapeutic use , Zoledronic Acid/therapeutic use , Osteogenesis Imperfecta/complications , Osteogenesis Imperfecta/drug therapy , Tooth Eruption , Bone Density Conservation Agents/adverse effects , Longitudinal Studies , Diphosphonates/adverse effects , Bone DensityABSTRACT
Niño, varón de 9 años de edad, que acude a consulta por primera vez a la Facultad de Odontología de la uCM, para recibir atención odontológica. La exploración clínica, pone de manifiesto que se encuentra en dentición mixta primera fase, y llama la atención la persistencia del incisivo central primario maxilar del lado izquierdo (6.1), estando erupcionados el resto de incisivos maxilares permanentes (Figura 1). En la radiografía panorámica solicitada para el diagnóstico de la situación y evaluación del desarrollo dentario, se confirma la presencia de un diente supernumerario que bloquea la trayectoria eruptiva del incisivo central maxilar izquierdo (retenido)(Figura 2). En colaboración con el Servicio de Cirugía Oral de la Facultad de odontología de la uCM se decide la exodoncia del diente primario, y tras la realización de un colgajo completo, la extracción también del supernumerario (Figuras 3 a 5). Considerando el potencial eruptivo de (..) (AU)
