ABSTRACT
Thiopronine has been used to treat 88 patients suffering from chronic hepatitis (65), liver cirrhosis in ascitic phase (14), alcoholic hepatosis(5) and acute hepatitis (4). The drug was employed at the attack stage i.v. at a daily dose of 1-2 grams, and at maintenance phase orally at a dose of 0.750-1 gram. It led to a gradual, significant improvement in clinical symptomatology and hepatofunctional haematochemical indices in all chronic forms, only decompensated cirrhosis showing a slight regression. In hepatic forms, normalisation of subjective and objective parameters was particularly fast, between the 4th and 7th days. Tolerance was very good in 98% of cases.
Subject(s)
Amino Acids, Sulfur/therapeutic use , Liver Diseases/drug therapy , Tiopronin/therapeutic use , Ascites/etiology , Hepatitis B/drug therapy , Hepatitis, Alcoholic/drug therapy , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/drug therapyABSTRACT
An uncommon abnormal hemoglobin, Hb Belfast (beta 15 Trp replaced by Arg) was discovered in a patient of Italian origin. The patient was a 42-year-old man who developed two episodes of jaundice after a prolonged administration of an antituberculous drugs. Family studies revealed that several members were asymptomatic carriers of Hb Belfast.
