[Crohn's disease of the esophagus. Apropos of a case]. / Maladie de Crohn de l'oesophage. A propos d'un cas.

A case of oesophageal Crohn's disease associated with large bowel lesions and with ocular, articular and cutaneous manifestations is reported. The patient, a 45 year old woman, was successfully treated with corticosteroids. The authors review the literature about oesophageal involvement in Crohn's disease and extra-intestinal manifestations.

Paroxysmal hypertension and spontaneous periodic hypothermia.

We report the case of a 42-year-old Zairian male who presented with paroxysmal attacks of hypertension accompanied by spontaneous recurrent hypothermia and profuse sweating of unknown origin. Routine and extensive examination failed to indicate a usual cause of arterial hypertension or for periodic hypothermia. Based on the hypothesis of an epileptic center influencing both the thermoregulatory and the vasomotor mechanisms, an anticonvulsant treatment was successfully installed. The present study makes a correlation between the present condition and certain neurologic abnormalities described in the literature.

[Drug-induced hepatitis due to benzarone (Fragivix): apropos of a clinical case report]. / Hépatite médicamenteuse liée à la benzarone (Fragivix): à propos d'une observation clinique.

A 46-year-old woman with a previous history of thyroiditis but without clinical evidence of preexisting liver disease presented with severe acute hepatitis while under benzarone therapy (Fragivix, 400 mg per day, p.o.). Because of negative serological work-up, a tentative diagnosis of "sporadic" non-A, non-B hepatitis was considered. Two months after resolution, a relapse of clinical and biochemical features of hepatitis occurring 10 days after the spontaneous resumption of therapy led to the diagnosis of drug-induced liver damage. This case represents the third reported case of severe hepatitis related to benzarone. The mechanism of liver toxicity was likely due to hypersensitivity.