1.
Bioorg Med Chem Lett
; 26(4): 1348-54, 2016 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-26781932
ABSTRACT
Novel bicyclic adenosine A(2A) antagonists with an aminoquinazoline moiety were designed and synthesized. The optimization of the initial lead compound based on in vitro and in vivo activity has led to the discovery of a potent and selective class of adenosine A(2A) antagonists. The structure-activity relationships of this novel series of bicyclic aminoquinazoline derivatives as adenosine A(2A) antagonists are described in detail.