ABSTRACT
The present study compared the effects on lipid metabolism of propofol in emulsion (Diprivan) and a fat emulsion (Intralipid) in doses containing the same amount of soya bean oil. Twenty patients received epidural anesthesia for gonarthroscopy and were randomly divided in two groups. Before the start of surgery the patients of group P received a bolus of 2 mg/kg of propofol followed by a one hour infusion of 6 mg/kg/h. In group I, a bolus of 0.2 mg/kg of Intralipid 10% was followed by an infusion of 0.6 ml/kg/h for one hour. These figures represent equivalent amounts of soya bean oil administered. Blood samples were obtained for analysis of serum triglycerides, cholesterol, phospholipids, free fatty acids, aproproteins, and the separated lipoprotein fractions. There were few significant differences between propofol in emulsion and Intralipid in the effects on lipid metabolism. The changes in the measured serum lipid components were mild and rarely lasted longer than 2 h after the end of infusion.
Subject(s)
Fat Emulsions, Intravenous/pharmacology , Lipid Metabolism , Propofol/pharmacology , Cholesterol/blood , Humans , Lipoproteins/blood , MaleABSTRACT
Sixty unpremedicated adult patients, undergoing arthroscopy, received propofol 2 mg kg-1 for induction of anaesthesia, before random allocation to three groups receiving one of the following: a continuous infusion of propofol supplemented with nitrous oxide in oxygen (group I); isoflurane and nitrous oxide in oxygen (group II); a continuous infusion of propofol in combination with repeated bolus doses of alfentanil (group III). The results showed no major differences in cardiovascular variables between the groups. Ventilation rate was highest in group II. Early recovery was less smooth and showed slight impairment in group III compared with the other groups. The data suggest that induction of anaesthesia with propofol followed by maintenance with isoflurane or continuous infusion of propofol is preferable for this procedure.
