ABSTRACT
HLA-A*02:374 differs from HLA-A*02:01:01 by one amino acid change at codon 112 where G is replaced by V.
Subject(s)
Alleles , HLA-A Antigens/genetics , Amino Acid Substitution , Base Sequence , Exons , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
The newly detected HLA-B*51:141 is distinguished from HLA-B*51:08 by a single-nucleotide exchange at codon 30 where D is replaced by Y.
Subject(s)
Alleles , HLA-B Antigens/genetics , Codon , Exons , Humans , Molecular Sequence Data , Polymorphism, Single NucleotideABSTRACT
Description of a new non-human primate major histocompatibility complex (MHC)-B (Patr-B) allele.
Subject(s)
Alleles , Histocompatibility Testing , Pan troglodytes/genetics , Amino Acid Substitution , Animals , Base Sequence , Cloning, Molecular , Codon , Consensus Sequence , DNA/genetics , DNA/isolation & purification , Databases, Factual , Exons , Molecular Sequence Data , Pan troglodytes/immunology , Polymerase Chain Reaction , Sequence Analysis, DNA , Serine/metabolismABSTRACT
This investigation was focused on the contribution of individual human leukocyte antigen (HLA)-DR and -DQ alleles to the human hepatitis C virus (HCV)(+) non-Hodgkin's lymphoma (NHL), with and without mixed cryoglobulinemia (MC), to study whether individual HLA class II alleles are expressed preferentially or equally in human HCV-specific NHL. For this purpose, peripheral blood mononuclear cells were obtained from two groups of patients with HCV(+) NHL and with or without MC (70 and 71 cases, respectively), and from 4575 blood donors. Eighty-three subjects with HCV infection only, and 118 patients with MC, only without lymphoma, were added as additional control groups. Individual HLA-DR and -DQ alleles were determined using high-resolution sequence-based typing and then data were collected by considering the HLA-DRB1 and DQB1 supertypes on the basis of common structural and functional features, proposed by in silico Bioinformatic studies. From the data, it is evidenced that the DR5-DQ3 HLA combination was strongly associated with the HCV (+) MC (+) NHL group of patients compared with bone marrow donor population (PSubject(s)
Cryoglobulinemia/genetics
, Cryoglobulinemia/virology
, Hepacivirus/genetics
, Histocompatibility Antigens Class II/genetics
, Lymphoma, Non-Hodgkin/genetics
, Alleles
, Cryoglobulinemia/etiology
, HLA-DQ Antigens/genetics
, HLA-DR Antigens/genetics
, HLA-DRB1 Chains
, Humans
, Lymphoma, Non-Hodgkin/complications
, Risk
ABSTRACT
A novel human leukocyte antigen (HLA)-A*680106 antigen was identified in two Italian individuals by polymerase chain reaction sequencing-based typing.
Subject(s)
Alleles , Celiac Disease/genetics , HLA-A Antigens/genetics , Adult , Base Sequence , Female , Genetic Predisposition to Disease , Humans , Italy , Molecular Sequence Data , Sequence AlignmentABSTRACT
Two new Patr-A, five new Patr-B and three new Patr-C alleles from Pan troglodytes are described.
Subject(s)
Alleles , Histocompatibility Antigens Class I/genetics , Major Histocompatibility Complex/genetics , Pan troglodytes/genetics , Pan troglodytes/immunology , Amino Acid Sequence , Animals , Base Sequence , Humans , Molecular Sequence DataABSTRACT
Sequence-based typing strategy is used to identify polymorphism of Patr-DRB1. Two new Patr-DRB1 are described.
